Figure 5

Large proteins tend to interact with relatively smaller partners. For each protein pair of different proteins, the length of the larger protein (protein1) is plotted on the x-axis. A,B,C) The difference in length with its partner (protein2) is plotted on y-axis. Larger proteins tend to have a larger length difference with their partners compared to proteins of smaller size. We see this trend amongst A) IntAct binary protein-protein interactions and B) Random binary interactions generated from the IntAct data C) binary interactions mapped onto all collected mammalian complexes. For all plots A-C, the trends are significant (t-test: P < 0.001).