Table 2 Overrepresented GO categories compared to control within the syngeneic transplantation group. The top 10 significantly overrepresented GO categories on the third level (p < 0.05, Fisher's exact test, with Benjamini and Hochberg correction) related to biological process (BP), cellular component (CC) and molecular function (MF) in the set of genes down- or up-regulated after syngeneic transplantation (sTX) compared to control are shown in Table 2 The numbers indicate the quantity of genes corresponding with the GO-terms.
From: Activation of counter-regulatory mechanisms in a rat renal acute rejection model
sTX_down | |||
|---|---|---|---|
Category | Term | Count | p-value |
BP | organic acid metabolism | 57 | 1,1E-10 |
BP | carboxylic acid metabolism | 56 | 1,5E-10 |
BP | amino acid and derivative metabolism | 41 | 7,1E-9 |
BP | amino acid metabolism | 31 | 2,2E-6 |
BP | nitrogen compound metabolism | 40 | 8,3E-6 |
BP | amine metabolism | 38 | 9,7E-6 |
BP | sulfur amino acid metabolism | 10 | 1,8E-5 |
BP | amino acid derivative metabolism | 18 | 6,0E-5 |
BP | amino acid catabolism | 13 | 1,1E-4 |
BP | nitrogen compound catabolism | 15 | 1,2E-4 |
CC | mitochondrion | 59 | 1,9E-7 |
CC | microbody | 14 | 4,0E-4 |
CC | peroxisome | 14 | 4,0E-4 |
MF | oxidoreductase activity | 59 | 3,2E-9 |
MF | catalytic activity | 195 | 1,5E-6 |
MF | lyase activity | 20 | 1,7E-3 |
sTX_up | |||
BP | mitotic cell cycle | 44 | 5,3E-7 |
BP | cell division | 30 | 6,1E-7 |
BP | cell cycle | 81 | 6,8E-7 |
BP | cell adhesion | 70 | 2,5E-6 |
BP | mitosis | 29 | 2,6E-6 |
BP | M phase of mitotic cell cycle | 29 | 2,7E-6 |
BP | cell proliferation | 83 | 1,1E-5 |
BP | M phase | 33 | 3,9E-5 |
BP | regulation of cell cycle | 54 | 7,9E-5 |
BP | regulation of progression through cell cycle | 54 | 7,9E-5 |
CC | extracellular matrix | 56 | 3,5E-16 |
CC | extracellular matrix (sensu Metazoa) | 54 | 2,7E-15 |
CC | intracellular non-membrane-bound organelle | 144 | 6,0E-13 |
CC | non-membrane-bound organelle | 144 | 6,0E-13 |
CC | collagen | 16 | 2,0E-7 |
CC | ribosome | 36 | 2,4E-5 |
CC | cytoskeleton | 76 | 4,1E-5 |
CC | spindle | 17 | 4,1E-5 |
CC | microtubule cytoskeleton | 40 | 4,2E-5 |
CC | chromosome | 36 | 4,4E-5 |
MF | structural molecule activity | 75 | 3,7E-8 |
MF | extracellular matrix structural constituent | 23 | 9,6E-8 |
MF | structural constituent of ribosome | 32 | 9,3E-5 |
MF | collagen binding | 8 | 1,7E-2 |
MF | pattern binding | 17 | 4,3E-2 |
MF | enzyme inhibitor activity | 29 | 4,7E-2 |