Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution

BMC Genomics

Table 2 Synonymous (K_s) and nonsynonymous (K_a) nucleotide substitution rate for ORFs of vertebrate GLTP genes

Species^a	Substitutions	bp^b	K _s	K _a	K_a/K_s
*GLTP*
Hom/Pan	3	627	0.01895	0.00000	0.00000
Hom/Mac	17	627	0.10175	0.00000	0.00000
Pan/Mac	16	627	0.09212	0.00000	0.00000
Bos/Sus	8	627	0.04131	0.00000	0.00000
Rat/Mus	33	627	0.22413	0.00196	0.00874
Dan(chr5)/(chr10)^c	194	627	1.99122	0.19415	0.09750
*GLTPi*
Hom/Pan	12	624	0.02959	0.01556	0.52585
Hom/Mac	44	624	0.08889	0.06576	0.73979
Pan/Mac	43	624	0.09884	0.05994	0.60643

^aGLTP = functional 5-exon/4-intron GLTP gene and GLTPi = intronless GLTP gene. Hom, Pan, Mac, Bos, Sus, Mus, Rat and Dan indicate Homo sapiens, Pan troglodytes, Macaca mulatta, Bos taurus, Sus scrofa, Mus musculus, Rattus norvegicus and Danio rerio, respectively. ^bNumber of base pairs compared. ^cThe relatively high K_a/K_s ratio of 5-exon/4-intron GLTP genes between Danio rerio GLTP genes on chromosome 5 and chromosome 10 suggests a functional change after duplication of one of the Danio rerio GLTP genes.

ISSN: 1471-2164