Table 1 Comparison of q and p values for the NCI60 and NCI39 studies. The NCI7 study suggested that the majority of correlates pairs identified in the NCI39 study with a correlation greater than 0.7 were reproducible. This correlation is associated with a q value of 0.05. A similar q value in the NCI60 study is associated with a correlation of just under 0.60. This assessment of acceptable correlations for gene:drug correlates worthy of potential further study is far lower than a conventional correction for multiple hypotheses would suggest.
From: Gene expression patterns within cell lines are predictive of chemosensitivity
| Â | p value | Bonferroni corrected p-value | q value | Correlation |
|---|---|---|---|---|
'NCI39' | 2.4 × 10-4 | 1 | 0.2 | 0.59 |
|  | 2 × 10-5 | 1 | 0.1 | 0.66 |
|  | 5.7 × 10-6 | 1 | 0.05 | 0.7 |
|  | 1.1 × 10-10 | 0.05 | nd | 0.84 |
NCI60 | ~2 × 10-4 | 1 | 0.1 | 0.5 |
|  | 1.2 × 10-5 | 1 | 0.05 | 0.57 |
|  | 5.7 × 10-6 | 1 | 0.05 | 0.59 |
|  | 1.1 × 10-10 | 0.05 | nd | 0.75 |