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Table 1 Comparison of q and p values for the NCI60 and NCI39 studies. The NCI7 study suggested that the majority of correlates pairs identified in the NCI39 study with a correlation greater than 0.7 were reproducible. This correlation is associated with a q value of 0.05. A similar q value in the NCI60 study is associated with a correlation of just under 0.60. This assessment of acceptable correlations for gene:drug correlates worthy of potential further study is far lower than a conventional correction for multiple hypotheses would suggest.

From: Gene expression patterns within cell lines are predictive of chemosensitivity

  p value Bonferroni corrected p-value q value Correlation
'NCI39' 2.4 × 10-4 1 0.2 0.59
  2 × 10-5 1 0.1 0.66
  5.7 × 10-6 1 0.05 0.7
  1.1 × 10-10 0.05 nd 0.84
NCI60 ~2 × 10-4 1 0.1 0.5
  1.2 × 10-5 1 0.05 0.57
  5.7 × 10-6 1 0.05 0.59
  1.1 × 10-10 0.05 nd 0.75