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Table 1 Sensitivity test for KTF , Kg , qp, Kd and H.

From: Selection of thermodynamic models for combinatorial control of multiple transcription factors in early differentiation of embryonic stem cells

T

KTF*

Pearson

Kg

Pearson

Kd

Pearson

qp

Pearson

H

Pearson

D

1

 

10

 

60/36

 

0.05

 

2

 

model 3

0.01

0.950042

1/60

0.967087

60/24

0.967081

1/35

0.967742

1

0.971055

0.1

0.950513

1/6

0.967081

60/30

0.967081

0.05

0.967081

2

0.967081

 

1

0.967081

10

0.967081

60/36

0.967081

0.10

0.966161

3

0.963737

 

10

0.957063

600

0.967081

60/42

0.967081

1

0.964237

4

0.964052

 

100

0.956187

1000

0.967081

60/48

0.967081

10

0.963906

5

0.968799

 

model 4

0.01

-0.95142

1/60

-0.96956

60/4

-0.96954

1/35

-0.96947

1

-0.97152

0.1

-0.95166

1/6

-0.96953

60/30

-0.96954

0.05

-0.96954

2

-0.96954

 

1

-0.96954

10

-0.96954

60/36

-0.96954

0.10

-0.96969

3

-0.96932

 

10

-0.95665

600

-0.96954

60/42

-0.96954

1

-0.97154

4

-0.97191

 

100

-0.95622

1000

-0.96954

60/48

-0.96954

10

-0.97186

5

-0.97484

 

model 5

0.01

-0.88219

1/60

-0.79531

60/24

-0.79529

1/35

-0.79534

1

-0.92423

0.1

-0.97198

1/6

-0.7953

60/30

-0.79529

0.05

-0.79529

2

-0.79529

 

1

-0.79529

10

-0.79529

60/36

-0.79529

0.10

-0.79518

3

-0.59358

 

10

-0.61602

600

-0.79529

60/42

-0.79529

1

-0.79363

4

-0.40171

 

100

-0.6125

1000

-0.79529

60/48

-0.79529

10

-0.78977

5

-0.2617

 

model 6

0.01

0

1/60

-0.96681

60/24

-0.96681

1/35

-0.96684

1

-0.96778

0.1

-0.97196

1/6

-0.9668

60/30

-0.96681

0.05

-0.96681

2

-0.96681

 

1

-0.96681

10

-0.96681

60/36

-0.96681

0.10

-0.96674

3

-0.95978

 

10

-0.66535

600

-0.96681

60/42

-0.96681

1

-0.96544

4

-0.93539

 

100

-0.61378

1000

-0.96681

60/48

-0.96681

10

-0.95794

5

-0.8747

 

model 7

0.01

0.96079

1/60

0.969306

60/24

0.969321

1/35

0.969576

1

0.97157

0.1

0.961556

1/6

0.96932

60/30

0.969321

0.05

0.969321

2

0.969321

 

1

0.969321

10

0.969321

60/36

0.969321

0.10

0.96904

3

0.968987

 

10

0.709205

600

0.96932

60/42

0.969321

1

0.968629

4

0.973865

 

100

0.614337

1000

0.96932

60/48

0.96932

10

0.968572

5

0.98013

 

model 8

0.01

-0.97205

1/60

-0.92839

60/24

-0.9284

1/35

-0.92828

1

-0.94378

0.1

-0.97213

1/6

-0.9284

60/30

-0.9284

0.05

-0.9284

2

-0.9284

 

1

-0.9284

10

-0.9284

60/36

-0.9284

0.10

-0.92855

3

-0.86111

 

10

-0.95055

600

-0.9284

60/42

-0.9284

1

-0.92884

4

-0.73939

 

100

-0.95336

1000

-0.9284

60/48

-0.9284

10

-0.92888

5

-0.68121

 

* The unit number of KTF is the maximum expression value /10.

Numbers in bold represent the highest correlations under each parameter set. The results indicate that the correct model can be identified even with drastic variation in parameters used in the model.