Figure 2

Conservation score and SH2 selectivity values of Tyr-SLiMs in disordered and ordered protein regions in 11 most studied RTKs. (A) SH2 binding Tyr-SLiMs are significantly more conserved than those that do not bind to SH2 domains in both order and disorder groups (both p < 0.001, Mann-Whitney test). (B) Percentage of SLiMs that reported to interact with SH2 domains.