Figure 1
From: Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2
HG2D Mouse Chromosome 2 congenic regions and phenotypic summary. The panel of HG2D-subcongenic strains was developed by selecting recombinant mice from an HG2D F2 intercross (HG2D donor region shown in green). The top horizontal lines in red represent body fat QTL identified previously in the HG2D F2 (Fatq1, Fatq2) (QTL peak is indicated by a circle) [9]. Solid boxed areas represent regions with known alleles (green or yellow = CAST/EiJ, and gray = C57BL/6J). Textured areas correspond to recombinant ends with unknown genotype. Below the five HG2D subcongenics the arrows indicate the direction of the additive genetic effects of the CAST alleles at distinct genomic intervals on each fat pad trait. These analyses were conducted in each subcongenic separately. See Additional file 1 for more details. Markers, locations on mm9 and putative candidate genes are shown below on the black horizontal line, corresponding to MMU 2, blue arrows indicate the approximate location of the genes.