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Figure 4 | BMC Genomics

Figure 4

From: Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq

Figure 4

Comparison of pico-scale transcription factor libraries. (A) CEBPA profiles of a 80 kb region on chromosome 1, based on progressively lower amounts of input ChIP-DNA and bacterial carrier (CEBPA-1, 300 and 1700 pg; CEBPA-3, 100 and 1900 pg; CEBPA-4, 100 and 900 pg; CEBP-5, 100 and 400 pg; CEBPA-6, 50 and 450 pg). (B) Quantitative comparisons of mean read coverage of CEBPA-1 versus CEBPA-3 /-4/-5/-6. ChIP-seq profiles in CEBPA-1 peak regions defined by MACS2. Quantile normalized, 1/1 diagonal indicated by dashed line (r = pearson correlation, raw data). (C) SeqMiner cluster heatmaps showing signal intensities for profiles CEBPA-1 and CEBPA-6 at 10000 bp regions centered on peak summits. For B and C, peak set as in Figure 3B.

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BMC Genomics

ISSN: 1471-2164

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