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Table 1 Average response to LPS from young and old cultures as measured by increase in expression of immune associated genes as compared to hour 0 post-LPS

From: Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome

Gene symbol Gene name Fold change*
   Hour 2 Hour 8
Transcription and activation pathways   
BIRC3 Baculoviral IAP repeat-containing protein 3 6.1 4.1
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 36.1 10
NFKBIZ Nuclear factor of kappa-B inhibitor zeta 23.8 4.1
NFKB2 Nuclear factor of κ light polypeptide gene enhancer in B-cells 2 2 2.1
Cytokines and chemokines, growth factors  
CCL2 Chemokine (C-C motif) ligand 2 28.5 26.7
CCL5 RANTES 35.4 48.4
CCL20 Chemokine (C-C motif) ligand 20 2034 1162.3
CSF2 Colony stimulating factor 2 97 6.1
CXCL1 Chemokine (C-X-C motif) ligand 1 2.5 - -
CXCL2 Chemokine (C-X-C motif) ligand 2 43.8 27.1
CXCL5 Chemokine (C-X-C motif) ligand 5 43.8 27.1
IFNB Interferon beta precursor 2 2
IL1A Interleukin 1, alpha 86.0 23.5
IL-6 Interleukin 6 83 131.6
IL-8 Interleukin 8 123.7 273.7
SAA3 Serum Amyloid A 3 505.6 2498.3
TNF-a Tumor Necrosis Factor, alpha 125.2 - -
TNFSF13B Tumor necrosis factor (ligand) superfamily, member 13 (BAFF) - - 4.6
Type I IFN-related genes   
IFI44 Similar to Interferon-induced protein 44 - - 15.2
IFIH1 Interferon induced with helicase C domain 1 - - 15.1
ISG15 ubiquitin-like modifier 6.2 63.2
MX2 Myxovirus (influenza virus) resistance 2 - - 121.2
OAS1 2′-5′-oligoadenylate synthetase 1 - - 24.6
OAS2 2′-5′-oligoadenylate synthetase 2 2.8 26.1
TNFSF10 Tumor necrosis factor ligand superfamily member 10 (TRAIL) - - 15.8
  1. *Data obtained by RNA-Seq and presented as fold induction of the indicated gene at either 2 or 8 hours post-LPS in comparison to expression levels at 0 hours post-LPS. All fold changes shown are FDR < 0.05; FC > 2; and CPM >1. - - indicates FDR > 0.05, FC < 2, or CPM < 1.