Figure 10

An example of a gene network (cell-to-cell signaling) showing the relationships between molecules over-expressed in cells treated with an adipogenic cocktail (DMIOA) + 5 μM 20(S)-hydroxycholesterol compared with those treated with DMIOA alone. The type of the association between two molecules is shown as a letter on the line that connects them. The number in parenthesis next to the letter represents the number of bibliographic references currently available in the Ingenuity Pathways Knowledge Base that support each one of the relationships. Direct or indirect relationships between molecules are indicated by solid or dashed lines connecting them, respectively. P = phosphorylation, A = gene activation, E = increase in expression, PP = protein-protein interaction, MB = membership in complex, LO = localization, L = proteolysis, RB = regulation of binding, TR = Translocation and T = Transcription. Triangular, rectangular, oval, and circular shapes indicate that, the molecule represented belongs to the family of phosphatases, growth factors, transmembrane receptors, and others, respectively.