Figure 5

An example of a gene network (lipid metabolism) showing the relationships between molecules over-expressed in cells treated with an adipogenic cocktail (DMIOA) compared with non-treated control cells. The type of the association between two molecules is shown by a letter on the line that connects them. The number in parenthesis next to the letter represents the number of bibliographic references currently available in the Ingenuity Pathways Knowledge Base that support each one of the relationships. Direct or indirect relationships between molecules are indicated by solid or dashed lines connecting them, respectively. P = phosphorylation, A = gene activation, E = increase in expression, PP = protein-protein interaction, MB = membership in complex, LO = localization, L = proteolysis, RB = regulation of binding, TR = Translocation and T = Transcription. Rhombus, triangular, rectangular, oval, and circular shapes indicate that the molecule belongs to a family of enzymes, phosphatases, growth factors, transmembrane receptors, and other families, respectively.