Figure 9

An example of a gene network (lipid metabolism) showing the relationships between molecules over-expressed in cells treated with an adipogenic cocktail (DMIOA) compared with those treated with a combination of DMIOA and 5 μM 20(S)-hydroxycholesterol. The type of the association between two molecules is shown as a letter on the line that connects them. The number in parenthesis next to the letter represents the number of bibliographic references currently available in the Ingenuity Pathways Knowledge Base that support each one of the relationships. Direct or indirect relationships between molecules are indicated by solid or dashed lines connecting them, respectively. A = activation, E = increase in expression, PP = protein-protein interaction, L = proteolysis, and UB = ubiquitination. Rhombus shape indicates that the molecule belongs to the family of enzymes, whereas circular shape indicates the molecule belongs to other families.