Genome-wide characterization of triple contacts.
(a) Observed over expected percentages of double and triple contacts that link 1 Mb regions with the same (either open or closed) or different (mixed) compartment labels for the KBM7-TM3C-1 library (Methods). Both double and triple contacts prefer to link open compartments to each other with triples showing slightly more enrichment for this trend. (b) Similar percentages as in (a) but when 1 Mb windows are segregated according to the number of DHSs they contain (Methods). Contacts linking regions with higher numbers of DHSs than the median number are enriched within the doubles and the triples of the KBM7-TM3C-1 library. Due to lack of DNase data for KBM7 cells, we use data from six other human cell lines for this analysis. Since the results are very similar among different cell lines, here we only plot the results for K562 which is also a leukemia cell line.