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Table 2 miRNA synergism results beyond consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

miRNA A miRNA B Borda rank Disease A Disease B Literature A Literature B
miR-106b miR-17 1 Various diseases Various diseases [40] [41]
miR-19a miR-19b 2 Various cancer types Various cancer types [6,42,43] [6,41-43]
miR-363 miR-92b 3 Alzheimers disease Lupus nephritis   
miR-181b miR-181d 4 Cardiac hypertrophy Various diseases   
let-7d let-7f 6 Various cancer types Various cancer types [44]  
miR-18a miR-18b 7 Various cancer types Cardiac hypertrophy [42]  
miR-128 miR-27b 8 Various diseases Cardiac hypertrophy   
miR-106a miR-291a-3p 9 Various diseases   [45]  
miR-30a miR-30e 100 Cardiac hypertrophy Cardiac hypertrophy [7,46] [7]
miR-30e miR-384-5p 132 Cardiac hypertrophy   [7] [47]
miR-30c miR-30e 184 Cardiac hypertrophy Cardiac hypertrophy [46] [7]
miR-294 miR-30e 318   Cardiac hypertrophy   [7]
miR-291a-3p miR-30e 364   Cardiac hypertrophy   [7]
miR-18b miR-297c 385 Cardiac hypertrophy    
miR-190 miR-194 391 Various cancer types Cardiac hypertrophy   [28]
miR-30d miR-30e 398 Cardiac hypertrophy Cardiac hypertrophy   [7]
miR-34a miR-34b-5p 399 Various diseases Various cancer types [8]  
miR-30e miR-495 411 Cardiac hypertrophy Various diseases [7] [48]
miR-139-3p miR-150 438 Cardiac hypertrophy Cardiac hypertrophy   [28]
miR-30e miR-466d-5p 453 Cardiac hypertrophy   [7]  
miR-1 miR-18a 457 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Various cancer types [36] [42]
miR-187 miR-18b 460 Non-alcoholic fatty liver disease (NAFLD) Cardiac hypertrophy   
miR-185 miR-18b 462 Cardiac hypertrophy Cardiac hypertrophy   
miR-100 miR-30e 489 Various diseases Cardiac hypertrophy [49] [7]
miR-1 miR-19a 492 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Various cancer types [36] [6,42,43]
miR-1 miR-206 512 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Various diseases [36]  
miR-194 miR-210 530 Cardiac hypertrophy Various diseases [28] [50]
miR-192 miR-218 548 Various cancer types Cardiac hypertrophy [28]  
miR-191 miR-218 549 Various cancer types Cardiac hypertrophy [48]  
miR-18b miR-219 550 Cardiac hypertrophy Various cancer types   
miR-18b miR-22 552 Cardiac hypertrophy Various diseases   [26,51]
miR-34a miR-449b 563 Various diseases Various cancer types [8]  
miR-150 miR-224 570 Cardiac hypertrophy Various cancer types [28]  
miR-18b miR-297b-5p 599 Cardiac hypertrophy    
miR-150 miR-296-5p 620 Cardiac hypertrophy Various diseases [28]  
miR-1 miR-29a 634 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Cardiac hypertrophy [36] [52]
miR-1 miR-29b 636 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Cardiac hypertrophy [36] [6,52]
miR-1 miR-29c 639 Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease Cardiac hypertrophy [36] [6,52]
  1. Synergism results for miRNA pairs that ranked in the upper quartile according to Borda voting scheme but not incorporated in the consensus modules (indicative examples). Each line reports the rank of each miRNA pair, disease-related information of the human orthologs as recorded in miR2Disease database (if found only cardiac pathophysiology related terms are reported) and evidence related to aging or cardiac pathophysiology provided by recent literature. Bold miRNAs are age-dependent based on linear regression analysis. We also added miRNA pairs with high rank yet not related to aging or cardiac pathophysiology (highlighted in italics).