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Table 3 Analysis of mouse consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

Module index Count Gene ontology term Percentage Fisher exact P-value Age-dependent miRNAs Age-dependent genes GenAge genes
1 18 One-carbon metabolic process 11.8 5.0E-2 N/A N/A N/A
2 22 Cellular aromatic compound metabolic process 10 5.0E-2 N/A GOS2  
3 5 N/A N/A N/A   N/A N/A
4 9 N/A N/A N/A miR-34a N/A N/A
5 68 Generation of precursor metabolites and energy 73.5 1.6E-77 N/A HADH, NDUFA10, NDUFV1 SLC25A4, UCP2
6 23 N/A N/A N/A N/A CDH22 N/A
7 4 N/A N/A N/A N/A N/A N/A
8 5 Heart development 40 5.0E-2 N/A N/A N/A
9 8 N/A N/A N/A N/A NDUFA10 N/A
10 16 Tissue development 30.8 7.2E-3 N/A N/A EPS8
11 20 N/A N/A N/A N/A N/A BUB1B
12 27 N/A N/A N/A N/A N/A BUB1B, MCM2
13 24 N/A N/A N/A N/A RHOU N/A
14 5 N/A N/A N/A N/A N/A N/A
15 6 N/A N/A N/A miR-466d-3p IER3 N/A
16 8 N/A N/A N/A N/A N/A N/A
17 5 N/A N/A N/A N/A N/A N/A
18 13 N/A N/A N/A miR-152 N/A N/A
19 36 N/A N/A N/A N/A RPL10, RPL37 N/A
20 5 N/A N/A N/A N/A N/A N/A
21 13 N/A N/A N/A N/A N/A N/A
22 5 N/A N/A N/A N/A N/A N/A
23 13 Response to DNA damage stimulus 53.8 1.4E-8 N/A N/A ERCC2
24 8 N/A N/A N/A N/A N/A MCM2
25 6 N/A N/A N/A N/A RPA3 N/A
26 6 N/A N/A N/A N/A N/A N/A
27 7 N/A N/A N/A N/A N/A N/A
28 5 N/A N/A N/A N/A N/A N/A
29 7 N/A N/A N/A N/A EEF2 N/A
30 8 N/A N/A N/A N/A N/A N/A
31 6 N/A N/A N/A N/A N/A N/A
32 5 N/A N/A N/A N/A N/A N/A
33 6 N/A N/A N/A miR-135a N/A N/A
34 4 N/A N/A N/A N/A N/A N/A
35 28 Cellular nitrogen compound metabolic process 78.6 6.2E-12 N/A N/A N/A
36 25 Cellular nitrogen compound metabolic process 76 2.1E-9 N/A N/A N/A
37 8 N/A N/A N/A N/A N/A N/A
38 24 N/A N/A N/A N/A N/A N/A
39 10 N/A N/A N/A N/A N/A MCM2
40 10 N/A N/A N/A N/A N/A N/A
  1. Summary of the 40 consensus modules. Count: The number of module members; Gene Ontology (GO) term: Statistically significant GO terms based on DAVID tool (P-value <= 0.05); Percentage: The percentage of modular genes characterized by the specific GO term; Fisher exact P-value: modified Fisher exact P-value (EASE score) as provided by DAVID (the complete mouse genome was used as background); Age-dependent miRNAs: Age-dependent miRNAs based on linear regression analysis; Age-dependent genes: Age-dependent genes based on linear regression analysis; GeneAge genes: longevity-associated genes according to GenAge database. N/A: not available.
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