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Figure 12 | BMC Genomics

Figure 12

From: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks

Figure 12

UPS-associated gene expression in AD-iPSC neurons. Cluster analysis based on Pearson correlation of UPS-related genes in AD-iPS neurons and H9 neurons. Up and down-regulated transcripts are depicted in red and green, respectively. RNA from AD-iPS5 neurons, AD-iPS26B neurons and H9 neurons of one well of one neuronal differentiation each was hybridized onto an Illumina human-8 BeadChip version 3. Known proteasome-related genes were selected from the microarray experiments of AD-iPS5 neurons, AD-iPS26B neurons and H9 neurons. Their Illumina average signal intensities were transformed to a logarithmic scale (log2) and clustered with the R heatmap2 function using Pearson correlation as similarity measure.

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BMC Genomics

ISSN: 1471-2164

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