Figure 6

Expression of Alzheimer risk genes in AD-iPSC derived neurons. Cluster analysis of Alzheimer risk genes in experiments AD-iPS5 neurons, iPS26B neurons and H9 neurons of one neuronal differentiation experiment each. Up and down-regulated transcripts are depicted in red and green, respectively. RNA from AD-iPS5 neurons, AD-iPS26B neurons and H9 neurons was hybridized onto an Illumina human-8 BeadChip version 3. Alzheimer-associated genes known from genome wide association studies were filtered from the microarray experiments of AD-iPS5 neurons, AD-iPS26B neurons and H9 neurons. Illumina detection p-values were mapped to a binary scale (0 = not expressed if p-value > 0.05, 1 = expressed if p-value < = 0.05). These values were clustered via the R heatmap2 function using Euclidean distance as distance measure.