Figure 3

Odds ratios for E11.5 heart enhancer overlap by H3K4me1 and H3K27ac from different cellular contexts. Mouse E11.5 heart enhancers are significantly enriched, compared to matched regions from the genomic background, for H3K4me1 and H3K27ac from all developmental stages listed (p<0.01 for all; Fisher’s exact test). As expected, the modifications from contexts flanking E11.5—E10 and E14.5—show the strongest enrichment, while the early stages and adult heart tissue have lower enrichment. Only three E11.5 heart enhancers are not marked by at least one of H3K4me1 or H3K27ac at E14.5.