Figure 1

Splicing phylogeny of the 8 founder strains. Hierarchical clustering, based on the Euclidean distance of the number of conserved junctions between each pair of strains, visualizes the splicing phylogeny across the 8 strains. All identified exon-exon junctions from each strain were included. As expected, two of the wild-derived strains, CAST and PWK, show to have the most divergent transcriptome structures. Unexpectedly, the clustering of the classical laboratory strains and WSB, are different than that of previous clustering based on genomic data, suggesting different selective pressures on the transcriptomic and genomic levels.