Figure 7

Distinct sets of DNA motifs were found in positive and negative T-DMRs. (a) 233 negative (red), 50 positive (blue), and 75 dual (black) found in all T-DMRs regulating gene expression for FDR < 0.01. Gray dots are other non-significant 6-mers in the study; (b) Similar results obtained in T-DMRs overlapped with DHSs for FDR < 0.05; (c) The numbers of significant motifs in both (a) and (b) and motifs playing the same regulation roles compared to expected numbers; (d) Heatmap of regulation role of significant motifs in both analyses; (e) Percentage of 6-mer motifs containing a CpG for each motif group in (a). Gray bar is percentage of all 6-mer motifs with a CpG.