Figure 2

Schematic drawing of domain organizations of aGPCRs encoded in the zebrafish genome. aGPCR domain architectures were predicted using CD-search, Pfam, and InterProScan prediction algorithms. Each panel shows the long N-termini with multiple functional domains, seven integral transmembrane helices embedded in the membrane, and the intracellular C-terminal end for each zebrafish aGPCR. For display purposes, the length of the N-termini of each panel does not correspond to a measured scale of amino acids; instead, the overall length of the receptors is shown in parentheses at the C-terminal end of each cartoon. The depicted domains are: seven-pass transmembrane domain (7TM), Cadherin domain, Calx-beta domain (CALXβ), CUB domain (for complement C1r/C1s, Uegf, Bmp1), Domain of unknown function 3479 (DUF3479), Epidermal growth factor (EGF), Calcium-binding EGF domain (EGF_Ca), Gal_lectin, GPCR-proteolytic site (GPS), Hormone receptor motif (HRM), immunoglobulin domains (IG), Immunoglobulin I-set domain (I-set), Laminin EGF domain (Laminin_EGF), Laminin_G_2, Latrophilin C-terminal domain (Latrophilin), Leucine Rich Repeats (LRR), Olfactomedin, Pentraxin domain, SEA domain, and Thrombospondin type 1 domain (TSP_1).