Figure 1

Genome-wide distributions of NdgR binding regions. (A) An overview of NdgR binding profiles across the S. coelicolor genome when grown on solid minimal media supplemented with N-acetylglucosamine and L-asparagine. Black and white dots indicate previously known and newly found NdgR binding regions, respectively. (B) Examples of binding profiles of previously known targets of NdgR. Red lines indicate the locations of putative binding motifs derived from FIMO and the values are the scores for the match of a position. Black arrows indicate the target genes within the transcription units that are directly regulated by NdgR. (C) MEME logo representation of the NdgR-DNA binding profile. This motif is present in 18 out of 19 enriched regions identified by ChIP-seq.