Figure 7
Integrated master regulatory network for HCC regulated proteins. Based on network information obtained for 7 different master regulators an integrated hybrid network was constructed. The network contained 114 proteins including 34 with connectivity to EGF/EGFR signalling (yellow coloured inner node). The master regulator, the connecting proteins (network elements) and regulated proteins are given as red, green and blue coloured inner node, respectively. Furthermore, each node is partitioned into four segments whereas the first segment seen from left refers to tumour specific proteins and is red-coloured. The second, third and fourth segments refer to either up- and down-regulated proteins, tumour specific gene expression changes and gene regulations in transgenic non-tumour liver tissue, respectively. Increased expression of either proteins or genes is given in red, whereas the blue colour denotes repressed expression.