Skip to main content

Table 2 Gene ontology analysis of the differentially expressed genes for FTC, PTC and ATC

From: Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma

Subtype (Exp) GO-ID p-value corr p-value x n X Description
FTC 9987 4.8469E-9 1.2888E-5 185 9365 264 cellular process
  44459 2.6863E-8 2.9147E-5 61 1998 264 plasma membrane part
  786 3.2885E-8 2.9147E-5 10 64 264 nucleosome
  32502 2.4620E-7 1.6366E-4 82 3235 264 developmental process
  6334 3.6737E-7 1.9537E-4 10 82 264 nucleosome assembly
  31497 5.7722E-7 2.5580E-4 10 86 264 chromatin assembly
  7155 8.6760E-7 2.6280E-4 29 711 264 cell adhesion
  22610 8.9259E-7 2.6280E-4 29 712 264 biological adhesion
  65004 9.8169E-7 2.6280E-4 10 91 264 protein-DNA complex
        assembly
  30054 9.9358E-7 2.6280E-4 24 521 264 cell junction
PTC 5576 8.4568E-20 3.4089E-16 124 2025 471 extracellular region
  32502 2.2428E-18 4.5203E-15 164 3231 471 developmental process
  44421 7.1367E-18 9.5893E-15 77 985 471 extracellular region part
  48731 1.0396E-17 1.0476E-14 134 2420 471 system development
  48856 1.4340E-17 1.1561E-14 142 2653 471 anatomical structure
        development
  7275 1.2464E-15 8.3739E-13 148 2969 471 multicellular organismal
        development
  9611 3.1138E-15 1.7931E-12 51 541 471 response to wounding
  31012 6.5039E-14 3.2771E-11 38 340 471 extracellular matrix
  48513 1.1744E-13 5.2599E-11 101 1790 471 organ development
  48518 1.4424E-13 5.8143E-11 116 2207 471 positive regulation of
        biological process
ATC 22403 2.6565E-31 1.6569E-27 105 436 1205 cell cycle phase
  7049 5.2100E-30 1.6247E-26 147 794 1205 cell cycle
  279 1.0473E-29 2.1774E-26 91 352 1205 M phase
  22402 1.9707E-29 3.0727E-26 121 583 1205 cell cycle process
  278 2.8071E-28 3.4578E-25 93 381 1205 mitotic cell cycle
  280 3.8808E-28 3.4578E-25 71 233 1205 nuclear division
  7067 3.8808E-28 3.4578E-25 71 233 1205 mitosis
  87 4.7977E-28 3.7404E-25 72 240 1205 M phase of mitotic cell cycle
  6950 5.0373E-27 3.2463E-24 240 1773 1205 response to stress
  48285 5.2048E-27 3.2463E-24 71 242 1205 organelle fission
FTC 44421 3.9892E-20 1.2027E-16 59 984 270 extracellular region part
  5576 1.5267E-18 2.3015E-15 84 2024 270 extracellular region
  5615 3.5497E-16 3.5674E-13 46 746 270 extracellular space
  9653 3.2978E-15 2.4857E-12 58 1216 270 anatomical structure morphogenesis
  48856 2.0741E-14 1.2507E-11 90 2654 270 anatomical structure development
  32502 3.6213E-13 1.8197E-10 99 3232 270 developmental process
  48731 1.5184E-12 6.5398E-10 81 2420 270 system development
  7275 2.0597E-12 7.7626E-10 92 2969 270 multicellular organismal development
  31012 1.4050E-11 4.7067E-9 26 340 270 extracellular matrix
  48513 4.7085E-11 1.4196E-8 64 1790 270 organ development
PTC 44421 7.8517E-13 2.8376E-9 61 985 404 extracellular region part
  5615 8.2894E-10 1.0196E-6 46 747 404 extracellular space
  48856 8.4640E-10 1.0196E-6 107 2655 404 anatomical structure development
  48731 2.1381E-9 1.9317E-6 99 2421 404 system development
  5576 2.7064E-9 1.9562E-6 87 2026 404 extracellular region
  9653 4.1464E-9 2.4975E-6 61 1217 404 anatomical structure morphogenesis
  48513 2.6665E-8 1.3767E-5 77 1791 404 organ development
  7275 5.2835E-8 2.3868E-5 110 2970 404 multicellular organismal development
  32502 5.9933E-8 2.4067E-5 117 3233 404 developmental process
  31012 7.5072E-8 2.7131E-5 26 340 404 extracellular matrix
ATC 5737 1.2083E-12 7.0080E-9 837 7628 1632 cytoplasm
  5622 1.4044E-9 4.0728E-6 1147 11273 1632 intracellular
  43296 4.8770E-9 9.4289E-6 27 85 1632 apical junction complex
  44444 8.0946E-9 1.1737E-5 574 5140 1632 cytoplasmic part
  16327 1.1319E-8 1.3130E-5 27 88 1632 apicolateral plasma membrane
  70160 2.1881E-8 1.7096E-5 24 74 1632 occluding junction
  5923 2.1881E-8 1.7096E-5 24 74 1632 tight junction
  44424 2.3581E-8 1.7096E-5 1107 10919 1632 intracellular part
  55114 5.1010E-7 3.2873E-4 98 647 1632 oxidation reduction
  5911 6.8676E-7 3.9832E-4 40 192 1632 cell-cell junction
  1. It is shown a set of the top ten categories for each case, overexpressed () and underexpressed ().
  2. It is shown the GO-ID, the p-value, adj. p-value, number of genes present in the set and the total of number of genes involved in that GO categorie. Finally, the name of the GO is also shown.
\