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Table 2 Gene ontology analysis of the differentially expressed genes for FTC, PTC and ATC

From: Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma

Subtype (Exp)

GO-ID

p-value

corr p-value

x

n

X

Description

FTC

9987

4.8469E-9

1.2888E-5

185

9365

264

cellular process

 

44459

2.6863E-8

2.9147E-5

61

1998

264

plasma membrane part

 

786

3.2885E-8

2.9147E-5

10

64

264

nucleosome

 

32502

2.4620E-7

1.6366E-4

82

3235

264

developmental process

 

6334

3.6737E-7

1.9537E-4

10

82

264

nucleosome assembly

 

31497

5.7722E-7

2.5580E-4

10

86

264

chromatin assembly

 

7155

8.6760E-7

2.6280E-4

29

711

264

cell adhesion

 

22610

8.9259E-7

2.6280E-4

29

712

264

biological adhesion

 

65004

9.8169E-7

2.6280E-4

10

91

264

protein-DNA complex

       

assembly

 

30054

9.9358E-7

2.6280E-4

24

521

264

cell junction

PTC

5576

8.4568E-20

3.4089E-16

124

2025

471

extracellular region

 

32502

2.2428E-18

4.5203E-15

164

3231

471

developmental process

 

44421

7.1367E-18

9.5893E-15

77

985

471

extracellular region part

 

48731

1.0396E-17

1.0476E-14

134

2420

471

system development

 

48856

1.4340E-17

1.1561E-14

142

2653

471

anatomical structure

       

development

 

7275

1.2464E-15

8.3739E-13

148

2969

471

multicellular organismal

       

development

 

9611

3.1138E-15

1.7931E-12

51

541

471

response to wounding

 

31012

6.5039E-14

3.2771E-11

38

340

471

extracellular matrix

 

48513

1.1744E-13

5.2599E-11

101

1790

471

organ development

 

48518

1.4424E-13

5.8143E-11

116

2207

471

positive regulation of

       

biological process

ATC

22403

2.6565E-31

1.6569E-27

105

436

1205

cell cycle phase

 

7049

5.2100E-30

1.6247E-26

147

794

1205

cell cycle

 

279

1.0473E-29

2.1774E-26

91

352

1205

M phase

 

22402

1.9707E-29

3.0727E-26

121

583

1205

cell cycle process

 

278

2.8071E-28

3.4578E-25

93

381

1205

mitotic cell cycle

 

280

3.8808E-28

3.4578E-25

71

233

1205

nuclear division

 

7067

3.8808E-28

3.4578E-25

71

233

1205

mitosis

 

87

4.7977E-28

3.7404E-25

72

240

1205

M phase of mitotic cell cycle

 

6950

5.0373E-27

3.2463E-24

240

1773

1205

response to stress

 

48285

5.2048E-27

3.2463E-24

71

242

1205

organelle fission

FTC

44421

3.9892E-20

1.2027E-16

59

984

270

extracellular region part

 

5576

1.5267E-18

2.3015E-15

84

2024

270

extracellular region

 

5615

3.5497E-16

3.5674E-13

46

746

270

extracellular space

 

9653

3.2978E-15

2.4857E-12

58

1216

270

anatomical structure morphogenesis

 

48856

2.0741E-14

1.2507E-11

90

2654

270

anatomical structure development

 

32502

3.6213E-13

1.8197E-10

99

3232

270

developmental process

 

48731

1.5184E-12

6.5398E-10

81

2420

270

system development

 

7275

2.0597E-12

7.7626E-10

92

2969

270

multicellular organismal development

 

31012

1.4050E-11

4.7067E-9

26

340

270

extracellular matrix

 

48513

4.7085E-11

1.4196E-8

64

1790

270

organ development

PTC

44421

7.8517E-13

2.8376E-9

61

985

404

extracellular region part

 

5615

8.2894E-10

1.0196E-6

46

747

404

extracellular space

 

48856

8.4640E-10

1.0196E-6

107

2655

404

anatomical structure development

 

48731

2.1381E-9

1.9317E-6

99

2421

404

system development

 

5576

2.7064E-9

1.9562E-6

87

2026

404

extracellular region

 

9653

4.1464E-9

2.4975E-6

61

1217

404

anatomical structure morphogenesis

 

48513

2.6665E-8

1.3767E-5

77

1791

404

organ development

 

7275

5.2835E-8

2.3868E-5

110

2970

404

multicellular organismal development

 

32502

5.9933E-8

2.4067E-5

117

3233

404

developmental process

 

31012

7.5072E-8

2.7131E-5

26

340

404

extracellular matrix

ATC

5737

1.2083E-12

7.0080E-9

837

7628

1632

cytoplasm

 

5622

1.4044E-9

4.0728E-6

1147

11273

1632

intracellular

 

43296

4.8770E-9

9.4289E-6

27

85

1632

apical junction complex

 

44444

8.0946E-9

1.1737E-5

574

5140

1632

cytoplasmic part

 

16327

1.1319E-8

1.3130E-5

27

88

1632

apicolateral plasma membrane

 

70160

2.1881E-8

1.7096E-5

24

74

1632

occluding junction

 

5923

2.1881E-8

1.7096E-5

24

74

1632

tight junction

 

44424

2.3581E-8

1.7096E-5

1107

10919

1632

intracellular part

 

55114

5.1010E-7

3.2873E-4

98

647

1632

oxidation reduction

 

5911

6.8676E-7

3.9832E-4

40

192

1632

cell-cell junction

  1. It is shown a set of the top ten categories for each case, overexpressed () and underexpressed ().
  2. It is shown the GO-ID, the p-value, adj. p-value, number of genes present in the set and the total of number of genes involved in that GO categorie. Finally, the name of the GO is also shown.