Table 3 IPA analysis of signaling pathways involved in cell-death and cell-to-cell signaling events

Cell Death

ATC

M, C, N

MMP1+, MMP3+, JNK-, FOXO1-, CASP3+, CASP7+

MMP1+, NUSAP1+, DEPDC1+, SPINT2-

FTC

M

BCR*, NFKB*, ADRB2-

FOSB-, CCL2-, LPL+

C

IL12*, IFA*, CD3*, CD44+, BAX+, HSP70*, JUN-

JUN-, CD44+

N

CTNNB1*, KCNIP4-, PGR*

GDF15+, KLF4-, SLIT2-

N

AKT*, E2F1*, TP73*, E2F*

SFRP2-, GATA5+

PTC

M, C

CG*, FSH*,LH*

PPARGC1A-, SLC4A4-, HMGA2+

M, C

PI3K family*, AKT*,BCR*, IGs*

PROM1-, IGSF1+

C

TGM2+, Caspases*

TIMP1+, SLC25A15, FHL1-

N

CD44+, AKT1*, GLI1*, POU5F1*

PAPSS2-

Cell-Cell Signaling

ATC

M

CG*, Secretase gamma*, PLAU+

PLAU+, PLAUR+, SPP1+, LRP1B-,PPAP2B-, SLC4A4-

E

IL1B+, CCL20+, IL1RN+

TSHR-, PDE8B-, FCGR2A+, TNFA1B6+, TG-

M

IFNA*, IFNB*, IL12*, MYD88+

CXCL5+, CD86+, CLEC7A+

M

IL8+, CD14+, TLR2+

IL8+, CCL21-, TLR2+

FTC

E, M, C

IL8*, IL13*, COL18A1*, HB*, CBL*

ZMAT3+, GJB6-, EPHB1-,EPHA3-

M

Estrogen receptor*, ITGB1*, CD46*, SPDEF*,FOXA1*

COL13A1+, CDH16-

M

{ }

XPR1+

PTC

M, C

NFKB*, GH*

CITED2-,GHR-, CDH3+

M, C

MAPK1*, F2*, HSF1*

FN1+, SHANK2-

E

IFNG*, IL1A*, p73*

SERPINA1+, CLMN-