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Table 3 IPA analysis of signaling pathways involved in cell-death and cell-to-cell signaling events

From: Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma

Category Subtype Compartment Hubs DEGs
Cell Death ATC M, C, N MMP1+, MMP3+, JNK-, FOXO1-, CASP3+, CASP7+ MMP1+, NUSAP1+, DEPDC1+, SPINT2-
  FTC M BCR*, NFKB*, ADRB2- FOSB-, CCL2-, LPL+
   C IL12*, IFA*, CD3*, CD44+, BAX+, HSP70*, JUN- JUN-, CD44+
   N CTNNB1*, KCNIP4-, PGR* GDF15+, KLF4-, SLIT2-
   N AKT*, E2F1*, TP73*, E2F* SFRP2-, GATA5+
  PTC M, C CG*, FSH*,LH* PPARGC1A-, SLC4A4-, HMGA2+
   M, C PI3K family*, AKT*,BCR*, IGs* PROM1-, IGSF1+
   C TGM2+, Caspases* TIMP1+, SLC25A15, FHL1-
   N CD44+, AKT1*, GLI1*, POU5F1* PAPSS2-
Cell-Cell Signaling ATC M CG*, Secretase gamma*, PLAU+ PLAU+, PLAUR+, SPP1+, LRP1B-,PPAP2B-, SLC4A4-
   E IL1B+, CCL20+, IL1RN+ TSHR-, PDE8B-, FCGR2A+, TNFA1B6+, TG-
   M IFNA*, IFNB*, IL12*, MYD88+ CXCL5+, CD86+, CLEC7A+
   M IL8+, CD14+, TLR2+ IL8+, CCL21-, TLR2+
  FTC E, M, C IL8*, IL13*, COL18A1*, HB*, CBL* ZMAT3+, GJB6-, EPHB1-,EPHA3-
   M Estrogen receptor*, ITGB1*, CD46*, SPDEF*,FOXA1* COL13A1+, CDH16-
   M { } XPR1+
  PTC M, C NFKB*, GH* CITED2-,GHR-, CDH3+
   M, C MAPK1*, F2*, HSF1* FN1+, SHANK2-
   E IFNG*, IL1A*, p73* SERPINA1+, CLMN-
  1. It is shown the compartment in which the found molecules are more abundant (M for plasma membrane; C for cytoplasm; N for nucleus and E for Extracellular Matrix), The most connected molecules (hubs) and the most differentially expressed genes. The sign (+,- and *) represent overexpression, underexpression and no-change with respect to control.
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