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Table 6 Validation of the status of the inhibition of matrix metalloproteinases pathway in PTC and ATC with other sample subset

From: Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma

Subtype Dataset 1 Dataset 2 Dataset 3
  (original) (validation 1) (validation 2)
FTC Not significant Not significant Not significant
PTC Not significant Not significant Not significant
ATC Active Not significant Active
  1. For this IPA/IKB analyisis, the Inhibition of Matrix Metalloproteinases (IMMPP) pathway was tested against two independent genome-wide gene expression databases. The IMMPP resulted with no statistical significance (at the pvalue = 0.01 level) for both FTC and PTC in all three cases (original dataset and two independent validation datasets) as expected. However, despite the statistical significance of the whole pathway, some molecules related to IMMPP in PTC resulted differentially expressed (depicted in Figure 7B). In the case of ATC, the IMMPP resulted dysregulated. However only two out of three experimental datasets (the original and one of the validation sets) reached statistical significance (pvalue 10−8 and 10−5, respectively).
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