The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA derived pathways and the evolution of Agaricomycotina

Table 2 Genes of the sterol biosynthesis pathway leading to ergosterol in Xanthophyllomyces dendrorhous

Numbering*	Enzyme	Gene	Gene in Phaffia genome	Comparison to other fungal genes**
1	Squalene synthase	ERG9	DEN_03884	58% Rh t., 54% C.n.
2	Squalene epoxidase	ERG1	XDEN_03392	48% Cr.n., 42% M.c.
3	Lanosterol synthase	ERG7	XDEN_03169	58% Cr.n., 53% Rh.t.
4	Lanosterol demethylase	ERG11	XDEN_04688	63% Cr.n. , 50% Rh.t.
5	C-14 reductase	ERG24	XDEN_01380	55% Cr.n., 50% Rh.t.
6	C-3 dehydrogenase	ERG26	XDEN_04885	57% Cr.n., 50% Rh.t.
7	C-3 keto reductase	ERG27	XDEN_03960	31% Cr.n., 27% C.g.
8	C-24 methyl transferase	ERG6	XDEN_00954	67% Cr.n., 59% Rh.t.
9	C-8 isomerase	ERG2	XDEN_05343	66% Rh.t., 43% Cr.n.
10	C-5 desaturase	ERG3	XDEN_02355	55% Cr.n., 51% Rh.t.
11	C-3 desaturase	ERG5	XDEN_01040	64% Cr.n., 55% Rh.t.
12	C-24 reductase	ERG4	XDEN_03446	58% Cr.n., 44% Rh.t.

*number of enzyme refers to reactions in Figure 3 (sterol pathway);
**identity to Rh.t. Rhodosporidium toruloides, Cr.n. Cryptococcus neoformans, M.c. Mucor circinelloides, C.g. Candida glabrata.

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