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Table 2 Top 10 CpG sites with the largest Δβ between nonagenarians and young controls

From: Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

ProbeID

Gene

betareg estimate

betareg p-value

Δβ

Wilcoxon p-value

cg07211259

PDCD1LG2

-1.086

3.24E-30

-0.290

1.53E-10

cg18826637

na

-1.280

2.23E-32

-0.289

1.53E-10

cg26063719

VIM

-1.036

6.09E-25

-0.284

1.53E-10

cg08548498

SLPI

-0.767

1.24E-15

-0.278

1.66E-10

cg19283806

CCDC102B

-1.253

9.82E-47

-0.267

1.53E-10

cg13591783

ANXA1

-0.826

5.17E-22

-0.266

1.53E-10

cg27192248

na

-1.246

2.57E-20

-0.265

1.59E-10

cg03274391

na

-1.263

1.18E-15

-0.264

1.54E-10

cg23654401

VOPP1

-0.781

2.94E-16

-0.262

1.54E-10

cg26269881

BHLHE40

-1.005

4.25E-25

-0.261

1.53E-10

cg18952796

NPTX2

1.121

6.89E-26

0.264

1.56E-10

cg17688525

L3MBTL4

0.865

1.36E-11

0.265

5.86E-10

cg27526665

THRB

0.940

2.64E-22

0.266

2.0E-10

cg09555124

IGF2R

0.944

4.34E-23

0.277

1.53E-10

cg23160016

GABRA2

1.041

1.01E-17

0.277

2.49E-10

cg10568066

RNF39

0.973

4.68E-13

0.278

1.60E-8

cg04875128

OTUD7A

1.514

7.2E-58

0.279

1.53E-10

cg21402921

GABRA5

0.868

4.90E-17

0.285

5.58E-10

cg00674365

ZNF471

1.033

6.27E-24

0.288

3.65E-10

cg06352730

na

1.437

1.26E-23

0.288

1.76E-10

  1. CpG sites with the largest difference in the methylation level (Δβ) between nonagenarians and controls. To clarify, Δβ refers to difference in the median of DNA methylation values between nonagenarians and young controls (difference in β-value), whereas betareg estimate refers to the estimate obtained from a regression model termed beta regression. Thus the absolute value of betareg estimate and the absolute value of Δβ for a given CpG site are not directly comparable, only the signs of the values are.