Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

BMC Genomics

Table 3 Hypermethylation-specific GO function terms in nonagenarians

GO term	Description	P-value	FDR q-value	Rank (out of 36)
GO:0043565	Sequence-specific DNA binding	1.18E-32	4.65E-29	1
GO:0001071	Nucleic acid binding transcription factor activity	9.38E-31	1.85E-27	2
GO:0003700	Sequence-specific DNA binding transcription factor activity	2.22E-30	2.92E-27	3
GO:0003677	DNA binding	6.48E-16	6.38E-13	4
GO:0000981	Sequence-specific DNA binding RNA polymerase II transcription factor activity	2.6E-15	2.05E-12	5
GO:0000976	Transcription regulatory region sequence-specific DNA binding	4.8E-13	2.7E-10	7
GO:0044212	Transcription regulatory region DNA binding	7.92E-12	3.47E-9	9
GO:0000975	Regulatory region DNA binding	2.22E-11	8.75E-9	10
GO:0001067	Regulatory region nucleic acid binding	2.22E-11	7.96E-9	11

This table includes only the hypermethylation-specific GO function terms that form a common cluster, associated with DNA binding and transcription. The presented p-values are unadjusted and the threshold for significance is 1.27e-5 (Bonferroni). The rank denotes the placement of a given GO term in the list of all significant GO terms. For all statistically significant GO function terms, see Additional file 3.

ISSN: 1471-2164