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Table 3 Hypermethylation-specific GO function terms in nonagenarians

From: Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

GO term Description P-value FDR q-value Rank (out of 36)
GO:0043565 Sequence-specific DNA binding 1.18E-32 4.65E-29 1
GO:0001071 Nucleic acid binding transcription factor activity 9.38E-31 1.85E-27 2
GO:0003700 Sequence-specific DNA binding transcription factor activity 2.22E-30 2.92E-27 3
GO:0003677 DNA binding 6.48E-16 6.38E-13 4
GO:0000981 Sequence-specific DNA binding RNA polymerase II transcription factor activity 2.6E-15 2.05E-12 5
GO:0000976 Transcription regulatory region sequence-specific DNA binding 4.8E-13 2.7E-10 7
GO:0044212 Transcription regulatory region DNA binding 7.92E-12 3.47E-9 9
GO:0000975 Regulatory region DNA binding 2.22E-11 8.75E-9 10
GO:0001067 Regulatory region nucleic acid binding 2.22E-11 7.96E-9 11
  1. This table includes only the hypermethylation-specific GO function terms that form a common cluster, associated with DNA binding and transcription. The presented p-values are unadjusted and the threshold for significance is 1.27e-5 (Bonferroni). The rank denotes the placement of a given GO term in the list of all significant GO terms. For all statistically significant GO function terms, see Additional file 3.