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Table 7 Characteristics of ageing-associated methylation sites

From: Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

 

Hypermethylated

Hypomethylated

n

3925

4615

CpG island location

CpG islands

Non-CGI

Genomic location

TSS, 1st exon

Gene body, outside genes

Associated genes

1832

2057

GO function terms

36

27

GO process terms

265

53

Canonical pathways (IPA)

19

3

Transcription factors

24

1

  1. The CpG island location and genomic location refer to the sites where hyper- and hypomethylated sites are most abundant. Notably, there are more hypomethylated CpG sites compared with hypermethylated CpG sites and therefore also more hypomethylation-associated genes, yet the hypermethylation-associated genes are enriched in more GO terms and canonical pathways, and they share more common transcription factors.
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BMC Genomics

ISSN: 1471-2164

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