Table 3 Antibiotic and heavy metal resistance genes identified within ETEC O157

intI1

+

+

Class 1 Integron Integrase

intI2

+

+

Class 2 Integron Integrase

bla _TEM

+

+

Ampicillin

+

ampC

+

+

Cephalosporins

O157:K88 734/3 only

gyrA

+

+

Quinolones

+

aphA1

+

+

Aminoglycosides

+

APH(4)-IA

+

Hygromycin B

O157 SvETEC only

strAB

+

+

Streptomycin

+

aadA

+

+

Streptomycin and Spectinomycin

+

dfrA

+

+

Trimethoprim

+

aacC

+

Apramycin

O157 SvETEC only

sul1

+

+

Sulphonamides

+

sul2

+

+

Sulphonamides

+

sul3

+

Sulphonamides

+

macAB

+

+

Macrolides

tet operon

+

+

Tetracycline

+

cmlA

+

Chloramphenicol

O157 SvETEC only

emr operon

+

+

RND Efflux Pump

gadX

+

+

Acid Resistance Regulator

mdt operon

+

+

RND Efflux Pump

cus operon

+

+

Heavy Metals

mer operon

+

+

Mercury

ter operon

+

Tellurium