Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level

Table 2 Translational regulation of functional gene groups for P. pastoris cells grown in excess glucose conditions

Functional group	Genes in group	Significantly regulated genes	Average translational log ₂ ratio of significantly regulated genes	Average ORF length of significantly regulated genes [bp]
Secretion: chaperones	79	31	0.225	885
Antioxidant	21	7	0.160	476
Transport(er)	60	22	0.137	1669
Pexophagy	23	9	−0.082	2302
Autophagy	69	25	−0.117	1690
Vacuole	105	48	−0.151	1781
Mitochondria	110	23	−0.165	1541
TCA	20	10	−0.339	1544
Secretion: glycosylation	46	28	−0.344	1884

Average translational states and ORF length of functional gene groups for P. pastoris cells grown in excess glucose. Translational trends were similar in the other conditions.

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