Identification of ncRNAs as potential therapeutic targets in multiple sclerosis through differential ncRNA – mRNA network analysis

Table 2 List of potential therapeutic ncRNA targets selected from the disease-specific network and that, in a previous analysis (results not published), were identified as differentially expressed genes either in relapse (vs. remission), in remission (vs. controls) or in both conditions

ncRNA	DEG_REL	DEG_REM	Outdegree
SNORD62	yes	no	39
SNORA40*	yes	yes	24
hsa-miR-1246	yes	yes	22
hsa-miR-20b	yes	no	17
hsa-miR-331-5p	yes	no	15
hsa-miR-1224-5p	yes	no	14
SNORA15	yes	no	7
hsa-miR-660	no	yes	7
SNORA24	yes	no	6
hsa-miR-21	no	yes	4
hsa-miR-26b	yes	yes	2
hsa-miR-18b	yes	yes	2
hsa-let-7f	no	yes	2
SNORA70	yes	no	2
hsa-miR-210	yes	yes	2
hsa-miR-1202	yes	no	2
hsa-miR-192	no	yes	1
hsa-miR-98	yes	no	1

DEG_REL: differentially expressed gene in relapse; DEG_REM: differentially expressed gene in remission. The ncRNAs that have previously appeared as key connectors in the global network and/or the controls’ network and/or are part of status-independent network are underlined. SNORA40 (marked*) is a good therapeutic target candidate that must be manipulated with care.

ISSN: 1471-2164