Classification of AML1/AML1-ETO genomic localization using co-factors. (A) Heatmap of significant (p < 10−20 from MACS) AML1/AML1-ETO ChIP-seq peaks clustered using k-means (k = 3) with normalized mean (over summit +/- 50 bp regions) read densities for AML1, AML1-ETO, N-CoR, p300 and the transcription initiation-associated histone modification H3K4me3. Following the color key, lowest read densities are represented in dark blue, whereas highest signals are in tan. (B) Distribution of clustered AML1/AML1-ETO loci among five classes of genomic elements. The y-axis represents the fraction of occupied loci among the each of the three clusters. (C) Profile of within-cluster averaged AML1, AML1-ETO, and co-regulatory protein enrichments. (D) Plot showing the fraction of ChIP-seq peaks containing the PU.1 motif as a function of total peak numbers for each cluster.