Figure 6

Gene expression and processes in the inner cell mass. (A) Of the 497 genes differentially expressed (≥2-fold; p ≤ 0.05) between ICM and TE (orange) several are up-regulated (bold) or down-regulated (regular) and 42 of these are also differentially expressed when inner cell masses treated with the MAPK-inhibitor PD0325901 (PD) are compared with control inner cell masses (magenta). This latter comparison retains 95 differentially expressed genes. Of the 42 shared genes 15 are up-regulated in both comparisons and 27 are contra-regulated (italics and underlined). (B) A gene ontology analysis with 41 ICM up-regulated genes (orange), 16 PD up-regulated (red) and 26 PD down-regulated (green) genes indicates several GO-terms of which 34 are enriched in both up-regulated gene analyses.