Table 1 Functional enrichment analysis of genes encompassing the identified CNVRs

KEGG

Toll-like receptor signaling pathway

04620

C = 102;O = 3;E = 0.10;R = 28.83;

0.0014

rawP = 0.0002

Fatty acid metabolism

00071

C = 43;O = 2;E = 0.04;R = 45.59;

0.0032

rawP = 0.0009

RIG-I-like receptor signaling pathway

04622

C = 71;O = 2;E = 0.07;R = 27.61;

0.0036

rawP = 0.0024

WikiPathways

Fatty Acid Beta Oxidation

WP143

C = 73;O = 3;E = 0.07;R = 40.28;

0.0005

rawP = 5.86e-05

Toll-like receptor signaling pathway

WP75

C = 116;O = 3;E = 0.12;R = 25.35;

0.0008

rawP = 0.0002

Regulation of toll-like receptor signaling pathway

WP1449

C = 154;O = 3;E = 0.16;R = 19.09;

0.0013

rawP = 0.0005

Pathway Commons

Immune System

522

C = 532;O = 6;E = 0.54;R = 11.05;

0.0012

rawP = 1.62e-05

Innate Immune System

1094

C = 190;O = 4;E = 0.19;R = 20.63;

0.0012

rawP = 4.32e-05

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

1115

C = 67;O = 3;E = 0.07;R = 43.89;

0.0012

rawP = 4.53e-05

Interferon Signaling

1123

C = 98;O = 3;E = 0.10;R = 30.00;

0.0013

rawP = 0.0001

Toll Receptor Cascades

1095

C = 90;O = 3;E = 0.09;R = 32.67;

0.0013

rawP = 0.0001

Interferon alpha/beta signaling

1122

C = 77;O = 3;E = 0.08;R = 38.19;

0.0013

rawP = 6.87e-05

Toll Like Receptor 9 (TLR9) Cascade

1084

C = 65;O = 2;E = 0.07;R = 30.16;

0.0089

rawP = 0.0020

Toll Like Receptor 2 (TLR2) Cascade

1136

C = 65;O = 2;E = 0.07;R = 30.16;

0.0089

rawP = 0.0020

TRIF mediated TLR3 signaling

1074

C = 56;O = 2;E = 0.06;R = 35.01;

0.0089

rawP = 0.0015