Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum

Table 5 Highly polymorphic loci in Cryptosporidium hominis genomes

Locus	Contig in 30976	SNP/kb (30976 vs Tu502)	Gene in C. hominis*	Ortholog in C. parvum*	Annotation
chr1_var1	contig_5	5.0	Chro.10024	cgd1_150	Hypothetical protein with a signal peptide
chr1_var2	contig_5	9.0	Chro.10427	cgd1_3810	Conserved hypothetical protein with a signal peptide
chr2_var1	contig_32	9.5	Chro.20050-52	cgd2_430-450	Mucin glycoprotein with a signal peptide
chr2_var2	contig_20	5.0	Intergenic downstream of Chro.20394	Intergenic downstream of cgd2_3690	WD repeat protein (cgd2_3690)
chr3_var1	contig_59	5.0	Intergenic downstream of Chro.30096	Within cgd3_720	Very large mucin with a signal peptide
chr3_var2	contig_31	6.5	Chro.30315	cgd3_2770	Hypothetical conserved protein
chr3_var3	contig_293 + contig_255	7.0	Chro.30479	cgd3_4260	Insulinase-like protease
chr6_var1	contig_3	9.0	Chro.60606	cgd6_5270	Hypothetical protein with a signal peptide
chr8_var1	contig_11	5.5	Chro.80070	cgd8_550	Large uncharacterized protein
chr8_var2	contig_2	6.0	Chro.80189	cgd8_1610	Sacsin-like HSP90 chaperone domain

*Additional polymorphic genes identified by comparative analysis of other isolates with C. hominis TU502: Chro.60016 (ortholog of cgd6_60), and Chro.60138 (ortholog of cgd6_1080).

ISSN: 1471-2164