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Table 5 Highly polymorphic loci in Cryptosporidium hominis genomes

From: Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum

Locus

Contig in 30976

SNP/kb (30976 vs Tu502)

Gene in C. hominis*

Ortholog in C. parvum*

Annotation

chr1_var1

contig_5

5.0

Chro.10024

cgd1_150

Hypothetical protein with a signal peptide

chr1_var2

contig_5

9.0

Chro.10427

cgd1_3810

Conserved hypothetical protein with a signal peptide

chr2_var1

contig_32

9.5

Chro.20050-52

cgd2_430-450

Mucin glycoprotein with a signal peptide

chr2_var2

contig_20

5.0

Intergenic downstream of Chro.20394

Intergenic downstream of cgd2_3690

WD repeat protein (cgd2_3690)

chr3_var1

contig_59

5.0

Intergenic downstream of Chro.30096

Within cgd3_720

Very large mucin with a signal peptide

chr3_var2

contig_31

6.5

Chro.30315

cgd3_2770

Hypothetical conserved protein

chr3_var3

contig_293 + contig_255

7.0

Chro.30479

cgd3_4260

Insulinase-like protease

chr6_var1

contig_3

9.0

Chro.60606

cgd6_5270

Hypothetical protein with a signal peptide

chr8_var1

contig_11

5.5

Chro.80070

cgd8_550

Large uncharacterized protein

chr8_var2

contig_2

6.0

Chro.80189

cgd8_1610

Sacsin-like HSP90 chaperone domain

  1. *Additional polymorphic genes identified by comparative analysis of other isolates with C. hominis TU502: Chro.60016 (ortholog of cgd6_60), and Chro.60138 (ortholog of cgd6_1080).