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Table 1 Significantly enriched Gene Ontology terms among co-expression network modules in CD14+ monocytes

From: Transcriptomic profiles of aging in purified human immune cells

Gene Ontology term Gene Count Direction of age effect Fold Enrichment Nominal P-value FDR
‘Blue’ network module ( 217 genes; 217↓0↑)
Ribonucleoprotein complex: 58 (58↓0↑) 5.6 5.71E-29 7.40E-26
Translation 41 (41↓0↑) 6.9 3.48E-23 5.20E-20
Ribosome biogenesis 16 (16↓0↑) 7.1 4.57E-09 6.84E-06
RNA processing 26 (26↓0↑) 2.8 5.25E-06 7.86E-03
Mitochondrion: 61 (61↓0↑) 3.2 5.67E-18 7.36E-15
Oxidative phosphorylation 15 (15↓0↑) 10.0 1.57E-10 2.35E-07
Respiratory chain complex I 8 (8↓0↑) 11.3 4.55E-06 5.90E-03
Turquoise’ network module (1,466 genes; 501↓965↑)
Nuclear lumen: 199 (48↓151↑) 1.4 9.05E-07 1.32E-03
RNA splicing 59 (17↓42↑) 1.8 1.43E-05 2.54E-02
  1. Results from gene set enrichment analysis are presented (from DAVID) for co-expression network modules with significantly enriched Gene Ontology (GO) terms (FDR < 0.05). No significant enrichment was observed among the ‘black’, ‘brown’, ‘yellow’, or ‘green’ network module genes; background genes included all 10,898 genes with expression detectable in 1,264 CD14+ monocyte samples.
  2. ↑ genes with expression positively associated with age; ↓ genes with expression negatively associated with age.