From: Transcriptomic profiles of aging in purified human immune cells
Gene Ontology term | Gene Count | Direction of age effect | Fold Enrichment | Nominal P-value | FDR |
---|---|---|---|---|---|
‘Blue’ network module ( 217 genes; 217↓0↑) | |||||
Ribonucleoprotein complex: | 58 | (58↓0↑) | 5.6 | 5.71E-29 | 7.40E-26 |
Translation | 41 | (41↓0↑) | 6.9 | 3.48E-23 | 5.20E-20 |
Ribosome biogenesis | 16 | (16↓0↑) | 7.1 | 4.57E-09 | 6.84E-06 |
RNA processing | 26 | (26↓0↑) | 2.8 | 5.25E-06 | 7.86E-03 |
Mitochondrion: | 61 | (61↓0↑) | 3.2 | 5.67E-18 | 7.36E-15 |
Oxidative phosphorylation | 15 | (15↓0↑) | 10.0 | 1.57E-10 | 2.35E-07 |
Respiratory chain complex I | 8 | (8↓0↑) | 11.3 | 4.55E-06 | 5.90E-03 |
‘ Turquoise’ network module (1,466 genes; 501↓965↑) | |||||
Nuclear lumen: | 199 | (48↓151↑) | 1.4 | 9.05E-07 | 1.32E-03 |
RNA splicing | 59 | (17↓42↑) | 1.8 | 1.43E-05 | 2.54E-02 |