Table 1 Canonical pathway associated with infection of Schmallenberg virus or a mutant lacking NSs
SBV vs uninfected | |||
|---|---|---|---|
Ingenuity canonical pathways | -log(p-value) | Ratio | Genes |
Interferon Signaling | 3.96E00 | 5.56E-02 | OAS1,MX1 |
Activation of IRF by Cytosolic Pattern Recognition Receptors | 3.42E00 | 2.74E-02 | IFIT2,ISG15 |
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 3.06E00 | 1.83E-02 | OAS1,OAS2 |
Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza | 1.95E00 | 3.45E-02 | RSAD2 |
Ephrin B Signaling | 1.47E00 | 1.22E-02 | GNAL |
CDK5 Signaling | 1.39E00 | 1.03E-02 | GNAL |
G Beta Gamma Signaling | 1.39E00 | 8.26E-03 | GNAL |
IL-1 Signaling | 1.37E00 | 9.17E-03 | GNAL |
Androgen Signaling | 1.29E00 | 6.9E-03 | GNAL |
Relaxin Signaling | 1.2E00 | 6.1E-03 | GNAL |
SBVdelNSs vs uninfected | Â | Â | Â |
Ingenuity Canonical Pathways | -log(p-value) | Ratio | Genes |
Interferon Signaling | 9.77E00 | 3.33E-01 | IFIT3,SOCS1,IFIT1,OAS1,MX1,IFI35,STAT2,IRF9,PSMB8,JAK2,TAP1,IRF1 |
Activation of IRF by Cytosolic Pattern Recognition Receptors | 9.32E00 | 2.05E-01 | ZBP1,IRF9,TBK1,IL6,IRF3,ADAR,NFKB1,ISG15,IFIH1,NFKBIA,CD40,DDX58,STAT2,IFIT2,NFKBIB |
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 8.35E00 | 1.56E-01 | OAS1,PRKCQ,C3,OAS2,IL6,CCL5,IRF3,NFKB1,RNASEL,TLR2,IFIH1,TLR4,DDX58,EIF2AK2,TLR3,RIPK2,ATM |
NF-κB Signaling | 7.81E00 | 1.22E-01 | AZI2,PRKCQ,RELB,IL36A,TNFAIP3,TBK1,IRAK3,NFKB1,TLR2,TLR4,TNIP1,NFKBIA,CD40,NGFR,MAP3K8,TRAF5,EIF2AK2,TLR3,NFKBIB,CASP8,ATM,TNFRSF11B |
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 7.74E00 | 8.77E-02 | SOCS1,ICAM1,IL1RL1,IL6,CCL5,JAK2,NFKB1,FCGR1A,IL18R1,Prss2,NFKBIA,CCL2,NGFR,TLR3,TRAF5,NFKBIB,ATM,TNFRSF11B,IL8,VCAM1,PRKCQ,WNT2B,IL15,IL36A,IRAK3,IL7,TLR2,IL16,TLR4,CSF1 |
Dendritic Cell Maturation | 7.58E00 | 1.04E-01 | B2M,ICAM1,HLA-A,RELB,IL15,IL36A,HLA-DMB,IL6,JAK2,NFKB1,FCGR1A,TLR2,TLR4,NFKBIA,CD40,NGFR,STAT2,TLR3,NFKBIB,IL23A,ATM,TNFRSF11B |
Antigen Presentation Pathway | 6.97E00 | 2.38E-01 | B2M,PSMB9,NLRC5,HLA-A,HLA-DMB,PSMB8,TAP1,TAP2,TAPBP,MR1 |
Role of PKR in Interferon Induction and Antiviral Response | 6.62E00 | 2.04E-01 | NFKBIA,TRAF5,EIF2AK2,TLR3,CASP8,NFKBIB,NFKB1,RNASEL,FCGR1A,IRF1 |
LXR/RXR Activation | 6.08E00 | 1.15E-01 | C3,IL1RL1,IL36A,IRF3,IL6,NFKB1,ABCA1,TLR4,CCL2,NGFR,MYLIP,LPL,CD14,PTGS2,TLR3,TNFRSF11B |
Hepatic Fibrosis/Hepatic Stellate Cell Activation | 5.93E00 | 1.1E-01 | IL8,VCAM1,ICAM1,IL1RL1,IGFBP5,IL6,CCL5,NFKB1,TLR4,CD40,CCL2,CSF1,HGF,NGFR,TGFB2,CD14,TNFRSF11B |