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Table 1 Canonical pathway associated with infection of Schmallenberg virus or a mutant lacking NSs

From: Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein

SBV vs uninfected
Ingenuity canonical pathways -log(p-value) Ratio Genes
Interferon Signaling 3.96E00 5.56E-02 OAS1,MX1
Activation of IRF by Cytosolic Pattern Recognition Receptors 3.42E00 2.74E-02 IFIT2,ISG15
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 3.06E00 1.83E-02 OAS1,OAS2
Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza 1.95E00 3.45E-02 RSAD2
Ephrin B Signaling 1.47E00 1.22E-02 GNAL
CDK5 Signaling 1.39E00 1.03E-02 GNAL
G Beta Gamma Signaling 1.39E00 8.26E-03 GNAL
IL-1 Signaling 1.37E00 9.17E-03 GNAL
Androgen Signaling 1.29E00 6.9E-03 GNAL
Relaxin Signaling 1.2E00 6.1E-03 GNAL
SBVdelNSs vs uninfected    
Ingenuity Canonical Pathways -log(p-value) Ratio Genes
Interferon Signaling 9.77E00 3.33E-01 IFIT3,SOCS1,IFIT1,OAS1,MX1,IFI35,STAT2,IRF9,PSMB8,JAK2,TAP1,IRF1
Activation of IRF by Cytosolic Pattern Recognition Receptors 9.32E00 2.05E-01 ZBP1,IRF9,TBK1,IL6,IRF3,ADAR,NFKB1,ISG15,IFIH1,NFKBIA,CD40,DDX58,STAT2,IFIT2,NFKBIB
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 8.35E00 1.56E-01 OAS1,PRKCQ,C3,OAS2,IL6,CCL5,IRF3,NFKB1,RNASEL,TLR2,IFIH1,TLR4,DDX58,EIF2AK2,TLR3,RIPK2,ATM
NF-κB Signaling 7.81E00 1.22E-01 AZI2,PRKCQ,RELB,IL36A,TNFAIP3,TBK1,IRAK3,NFKB1,TLR2,TLR4,TNIP1,NFKBIA,CD40,NGFR,MAP3K8,TRAF5,EIF2AK2,TLR3,NFKBIB,CASP8,ATM,TNFRSF11B
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 7.74E00 8.77E-02 SOCS1,ICAM1,IL1RL1,IL6,CCL5,JAK2,NFKB1,FCGR1A,IL18R1,Prss2,NFKBIA,CCL2,NGFR,TLR3,TRAF5,NFKBIB,ATM,TNFRSF11B,IL8,VCAM1,PRKCQ,WNT2B,IL15,IL36A,IRAK3,IL7,TLR2,IL16,TLR4,CSF1
Dendritic Cell Maturation 7.58E00 1.04E-01 B2M,ICAM1,HLA-A,RELB,IL15,IL36A,HLA-DMB,IL6,JAK2,NFKB1,FCGR1A,TLR2,TLR4,NFKBIA,CD40,NGFR,STAT2,TLR3,NFKBIB,IL23A,ATM,TNFRSF11B
Antigen Presentation Pathway 6.97E00 2.38E-01 B2M,PSMB9,NLRC5,HLA-A,HLA-DMB,PSMB8,TAP1,TAP2,TAPBP,MR1
Role of PKR in Interferon Induction and Antiviral Response 6.62E00 2.04E-01 NFKBIA,TRAF5,EIF2AK2,TLR3,CASP8,NFKBIB,NFKB1,RNASEL,FCGR1A,IRF1
LXR/RXR Activation 6.08E00 1.15E-01 C3,IL1RL1,IL36A,IRF3,IL6,NFKB1,ABCA1,TLR4,CCL2,NGFR,MYLIP,LPL,CD14,PTGS2,TLR3,TNFRSF11B
Hepatic Fibrosis/Hepatic Stellate Cell Activation 5.93E00 1.1E-01 IL8,VCAM1,ICAM1,IL1RL1,IGFBP5,IL6,CCL5,NFKB1,TLR4,CD40,CCL2,CSF1,HGF,NGFR,TGFB2,CD14,TNFRSF11B
  1. This table shows the top 10 IPA canonical pathways associated with SBV and SBVdelNSs infection, the p-value of Fisher’s exact test, the ratio (number of the genes in the dataset mapping to each specific pathway divided by the total number of genes in the pathway) and lists the DE genes from this study involved in respective pathway.