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Table 2 Virulence and immunomodulation-related transcripts of F.hepatica

From: Comparative transcriptome profiling approach to glean virulence and immunomodulation-related genes of Fasciola hepatica

Transcript no Accession no Description Subgroup HPI Immunological property Resource
1584 XP_002572744.1 Sarm1 [Schistosoma mansoni] CSR * Toll/interleukin-1 receptor homology IPS
3866 CAX70351.1 LIN1-like protein [Schistosoma japonicum] PDR (HT)   Proline binding NCBI
5195 BC055836.1 Neutrophil cytosolic factor 1, mRNA (cDNA clone MGC:67831 IMAGE:3983481), complete cds [Mus musculus] PDR (VT) * Leukocyte mediated cytotoxicity UniProt
6556 GAA27790.2 Hypothetical protein CLF_107202 [Clonorchis sinensis] CSR * Toll/interleukin-1 receptor homology IPS
6733 GAA34190.1 Hypothetical protein CLF_100679 [Clonorchis sinensis] PSR/CSR   Toll/interleukin-1 receptor homology IPS
7694 XP_002573383.1 Hypothetical protein [Schistosoma mansoni] PDR (HT) * Complement associated NCBI/GeneDB
7920 GAA36580.2 T-cell immunomodulatory protein [Clonorchis sinensis] PDR (HT) * Modulator of T-cell function UniProt
8653 NP_001137161.1 Histocompatibility 2, Q region locus 4 precursor [Mus musculus] PDR (HT) * MHC class I homology IPS
10264 CCD82398.1 Putative tgf-beta family [Schistosoma mansoni] CSR * TGF-β homology IPS
10702 NP_112313.1 Macrophage migration inhibitory factor [Rattus norvegicus] CSR * Macrophage migration inhibition IPS
11419 GAA47989.1 Suppressor of cytokine signaling 7 [Clonorchis sinensis] CSR   Suppressor of cytokine signalling IPS
11610/45296//64440 GAA27846.2 TGF-beta receptor type-1 [Clonorchis sinensis] CSR/CSR//PSR/CSR * TGF-β receptor homology IPS/IPS//IPS
12300 AAW24666.1 SJCHGC04616 protein [Schistosoma japonicum] CSR * Interleukin-4/interleukin-13 homology IPS
13771 1401243A Major histocompatibility complex HLA I [Mus musculus] PDR (VT) * MHC class I homology IPS
16002 CCD77150.1 Hypothetical protein Smp_194540 [Schistosoma mansoni] CSR * Toll/interleukin-1 receptor homology IPS
19626/20908 GAA37431.2 TGF-beta receptor type-1 [Clonorchis sinensis] CSR/CSR * TGF-β receptor homology IPS/IPS
19810/53747/68185 GAA28730.2 Thrombospondin-2 [Clonorchis sinensis] PDR (HT)/PDR (HT)/PDR(HT) * TGF-β stimulation NCBI/NCBI/NCBI
20661 GAA53897.1 Activin receptor type-2B [Clonorchis sinensis] PDR (HT)/PDR (VT)/PSR/CSR * TGF-β receptor homology IPS
22528 AAA39677.1 MHC K-bm6 transplantation antigen, partial [Mus musculus] PDR (VT) * MHC class I homology IPS
23314 GAA55000.1 Hypothetical protein CLF_106334 [Clonorchis sinensis] PSR/CSR ** CD147 homology NCBI/IPS
26180 XP_005669379.1 PREDICTED: TGF-beta receptor type-2 [Sus scrofa] CSR * TGF-β receptor homology IPS
26955 GAA56301.1 Bone morphogenetic protein receptor type-1 invertebrate [Clonorchis sinensis] CSR * TGF-β receptor homology IPS
27939 NP_001153015.1 Dipeptidyl peptidase 4 isoform 2 [Mus musculus] PDR (VT) * T-cell receptor homology NCBI
31945 CAA36183.1 Unnamed protein product [Mus musculus] CSR * IL-10 stimulation IPS
32835 NP_033865.2 beta-2-microglobulin precursor [Mus musculus] PDR (HT) * MHC class I homology IPS
32989 AIE76460.1 CD59-like protein [Fasciola hepatica] PDR (HT) * Complement associated IPS
34645 CCD61018.1 Hypothetical protein Smp_194470 [Schistosoma mansoni] PDR (HT) * TGF-β stimulation NCBI
34729 BAB30997.1 Unnamed protein product [Mus musculus] CSR   T-cell receptor homology IPS
37409 GAA49741.1 Tumor necrosis factor receptor superfamily member 16 [Clonorchis sinensis] PDR (HT) * TNF receptor homology NCBI
37746 GAA51051.1 Activin receptor type-2B [Clonorchis sinensis] CSR * TGF-β receptor homology IPS
38312 XP_003945784.1 PREDICTED: h-2 class I histocompatibility antigen, K-D alpha chain-like isoform 6 [Mus musculus] PDR (VT) * MHC class I homology IPS
38341 XP_002570313.1 Hypothetical protein [Schistosoma mansoni] CSR * Toll/interleukin-1 receptor homology IPS
38525 CCD58880.1 Cleavage and polyadenylation specificity factor,putative [Schistosoma mansoni] CSR * Suppressor of IKBKE 1 IPS
38573 AAA39573.1 MHC H2-D-q alpha-chain, partial [Mus musculus] PDR (HT) * MHC class I homology NCBI
40314 GAA48275.1 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [Clonorchis sinensis] CSR * TNF-α homology IPS
40900 XP_002577301.1 Hypothetical protein [Schistosoma mansoni] PDR (HT)/PSR * TGF-β stimulation NCBI/GeneDB
42935/76935 GAA51525.1 CD2 antigen cytoplasmic tail-binding protein 2 [Clonorchis sinensis] PDR (HT)/PDR (HT) * Proline binding NCBI/NCBI
44058 XP_002578816.1 Bone morphogenetic protein antagonist noggin [Schistosoma mansoni] CSR * TGF-β antagonist IPS
44260 3Q5T_A Chain A, V BetaV BETA HOMODIMERIZATION-Based Pre-Tcr Model Suggested By Tcr Beta Crystal Structures [Mus musculus] PDR (HT)   T-cell receptor homology NCBI
47252 XP_002575081.1 Suppressor of cytokine signaling [Schistosoma mansoni] CSR * Suppressor of cytokine signalling IPS
49819 GAA49058.1 Activin receptor type-1, partial [Clonorchis sinensis] CSR * TGF-β receptor homology IPS
53490/55117 XP_003946490.1 PREDICTED: h-2 class I histocompatibility antigen, D-D alpha chain-like isoform 7 [Mus musculus] PDR (VT)/PDR (HT) * MHC class I homology IPS/IPS
54791 AAA39576.1 MHC H2-K-d transplantation antigen H2-Kd, partial [Mus musculus] PDR (VT) * MHC class I homology NCBI
55207 XP_002570016.1 Protein kinase [Schistosoma mansoni] CSR * TGF-β receptor homology IPS
56418 XP_002570128.1 Bone morphogenetic protein antagonist noggin [Schistosoma mansoni] CSR * TGF-β antagonist IPS
56437 NP_001077023.1 Transforming growth factor-beta receptor-associated protein 1 homolog [Danio rerio] CSR   TGF-β receptor homology IPS
58384 1404428A Cytotoxic T lymphocyte [Murid herpesvirus 1] PDR (HT) * MHC class I homology IPS
58628 GAA54758.1 TNF receptor-associated factor 4 [Clonorchis sinensis] CSR   TNF receptor homology IPS
58983 NM_001033288.3 Somatomedin B and thrombospondin, type 1 domain containing (Sbspon), mRNA [Mus musculus] PDR (VT) * TGF-β stimulation UniProt
59522 XP_003946048.1 PREDICTED: h-2 class I histocompatibility antigen, K-D alpha chain-like isoform 4 [Mus musculus] PDR (VT) * MHC class I homology IPS
59632 BAE26952.1 Unnamed protein product [Mus musculus] CSR * CD48 homology NCBI/IPS
59650 CAE82020.1 Unnamed protein product [Mus musculus] PDR (VT) * MHC class I homology NCBI
60918 GAA43145.2 Protein DVR-1 [Clonorchis sinensis] CSR * TGF-β homology IPS
61208 AAA39567.1 H-2D cell surface glycoprotein, partial [Mus musculus] PDR (HT) * MHC class I homology IPS
64619 BAE20821.1 Unnamed protein product [Mus musculus] PDR (HT) * T-cell receptor homology IPS
65009 1503111B H2Dd gene [Mus musculus] PDR (HT) * MHC class I homology IPS
70639 CCD82741.1 T-cell immunomodulatory protein [Schistosoma mansoni] PDR (HT) * Modulator of T-cell function UniProt
72283 CAX74995.1 LIN1-like protein [Schistosoma japonicum] PDR (HT) * Proline binding NCBI
73151 CAA24128.1 H2-Ld [Mus musculus] PDR (VT) * MHC class I homology IPS
73578 EDL36365.1 mCG8696 [Mus musculus] PDR (HT) * T-cell receptor homology IPS
73673 EDL76957.1 Transforming growth factor, beta receptor II, isoform CRA_b [Rattus norvegicus] CSR * TGF-β receptor homology IPS
76453 BAE34022.1 Unnamed protein product [Mus musculus] CSR * TGF-β receptor homology IPS
77913 NP_034683.1 Interleukin-18 receptor accessory protein precursor [Mus musculus] CSR * IL-18 receptor accessory protein homology IPS
79120 Smp_060190.1 ctg4a [Schistosoma mansoni] PDR (HT) * Toll like receptor 4 (TLR4) regulation NCBI/GeneDB
  1. Virulence and immunomodulation-related transcripts of F. hepatica (VIRs) with accession and description of the corresponding sequences, identified by the transcript subgroups, are listed. The predicted immunomodulatory property function and the possibility for the host-parasite interaction (HPI) for VIRs are shown. Data resources for the categorisation and/or prediction of function are indicated. Most proteins inferred from VIRs (n = 63) were predicted to be possibly located in the extracellular space except a VIR protein which is possibly located at the cell plasma membrane. Accesion with description was obtained from the blast searches in the NCBI protein database or GeneDB (for only #79120). Asterisk (*) indicates potential association with extracellular localisation. Double asterisk (**) indicates potential association with plasma membrane location. No asterisk in the HPI column indicates the signs of cytoplasmic locations for the related transcripts except #3866, which showed the signs of being located in mitochondria and/or nucleus. IPS: InterProScan.