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Table 2 Virulence and immunomodulation-related transcripts of F.hepatica

From: Comparative transcriptome profiling approach to glean virulence and immunomodulation-related genes of Fasciola hepatica

Transcript no

Accession no

Description

Subgroup

HPI

Immunological property

Resource

1584

XP_002572744.1

Sarm1 [Schistosoma mansoni]

CSR

*

Toll/interleukin-1 receptor homology

IPS

3866

CAX70351.1

LIN1-like protein [Schistosoma japonicum]

PDR (HT)

 

Proline binding

NCBI

5195

BC055836.1

Neutrophil cytosolic factor 1, mRNA (cDNA clone MGC:67831 IMAGE:3983481), complete cds [Mus musculus]

PDR (VT)

*

Leukocyte mediated cytotoxicity

UniProt

6556

GAA27790.2

Hypothetical protein CLF_107202 [Clonorchis sinensis]

CSR

*

Toll/interleukin-1 receptor homology

IPS

6733

GAA34190.1

Hypothetical protein CLF_100679 [Clonorchis sinensis]

PSR/CSR

 

Toll/interleukin-1 receptor homology

IPS

7694

XP_002573383.1

Hypothetical protein [Schistosoma mansoni]

PDR (HT)

*

Complement associated

NCBI/GeneDB

7920

GAA36580.2

T-cell immunomodulatory protein [Clonorchis sinensis]

PDR (HT)

*

Modulator of T-cell function

UniProt

8653

NP_001137161.1

Histocompatibility 2, Q region locus 4 precursor [Mus musculus]

PDR (HT)

*

MHC class I homology

IPS

10264

CCD82398.1

Putative tgf-beta family [Schistosoma mansoni]

CSR

*

TGF-β homology

IPS

10702

NP_112313.1

Macrophage migration inhibitory factor [Rattus norvegicus]

CSR

*

Macrophage migration inhibition

IPS

11419

GAA47989.1

Suppressor of cytokine signaling 7 [Clonorchis sinensis]

CSR

 

Suppressor of cytokine signalling

IPS

11610/45296//64440

GAA27846.2

TGF-beta receptor type-1 [Clonorchis sinensis]

CSR/CSR//PSR/CSR

*

TGF-β receptor homology

IPS/IPS//IPS

12300

AAW24666.1

SJCHGC04616 protein [Schistosoma japonicum]

CSR

*

Interleukin-4/interleukin-13 homology

IPS

13771

1401243A

Major histocompatibility complex HLA I [Mus musculus]

PDR (VT)

*

MHC class I homology

IPS

16002

CCD77150.1

Hypothetical protein Smp_194540 [Schistosoma mansoni]

CSR

*

Toll/interleukin-1 receptor homology

IPS

19626/20908

GAA37431.2

TGF-beta receptor type-1 [Clonorchis sinensis]

CSR/CSR

*

TGF-β receptor homology

IPS/IPS

19810/53747/68185

GAA28730.2

Thrombospondin-2 [Clonorchis sinensis]

PDR (HT)/PDR (HT)/PDR(HT)

*

TGF-β stimulation

NCBI/NCBI/NCBI

20661

GAA53897.1

Activin receptor type-2B [Clonorchis sinensis]

PDR (HT)/PDR (VT)/PSR/CSR

*

TGF-β receptor homology

IPS

22528

AAA39677.1

MHC K-bm6 transplantation antigen, partial [Mus musculus]

PDR (VT)

*

MHC class I homology

IPS

23314

GAA55000.1

Hypothetical protein CLF_106334 [Clonorchis sinensis]

PSR/CSR

**

CD147 homology

NCBI/IPS

26180

XP_005669379.1

PREDICTED: TGF-beta receptor type-2 [Sus scrofa]

CSR

*

TGF-β receptor homology

IPS

26955

GAA56301.1

Bone morphogenetic protein receptor type-1 invertebrate [Clonorchis sinensis]

CSR

*

TGF-β receptor homology

IPS

27939

NP_001153015.1

Dipeptidyl peptidase 4 isoform 2 [Mus musculus]

PDR (VT)

*

T-cell receptor homology

NCBI

31945

CAA36183.1

Unnamed protein product [Mus musculus]

CSR

*

IL-10 stimulation

IPS

32835

NP_033865.2

beta-2-microglobulin precursor [Mus musculus]

PDR (HT)

*

MHC class I homology

IPS

32989

AIE76460.1

CD59-like protein [Fasciola hepatica]

PDR (HT)

*

Complement associated

IPS

34645

CCD61018.1

Hypothetical protein Smp_194470 [Schistosoma mansoni]

PDR (HT)

*

TGF-β stimulation

NCBI

34729

BAB30997.1

Unnamed protein product [Mus musculus]

CSR

 

T-cell receptor homology

IPS

37409

GAA49741.1

Tumor necrosis factor receptor superfamily member 16 [Clonorchis sinensis]

PDR (HT)

*

TNF receptor homology

NCBI

37746

GAA51051.1

Activin receptor type-2B [Clonorchis sinensis]

CSR

*

TGF-β receptor homology

IPS

38312

XP_003945784.1

PREDICTED: h-2 class I histocompatibility antigen, K-D alpha chain-like isoform 6 [Mus musculus]

PDR (VT)

*

MHC class I homology

IPS

38341

XP_002570313.1

Hypothetical protein [Schistosoma mansoni]

CSR

*

Toll/interleukin-1 receptor homology

IPS

38525

CCD58880.1

Cleavage and polyadenylation specificity factor,putative [Schistosoma mansoni]

CSR

*

Suppressor of IKBKE 1

IPS

38573

AAA39573.1

MHC H2-D-q alpha-chain, partial [Mus musculus]

PDR (HT)

*

MHC class I homology

NCBI

40314

GAA48275.1

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [Clonorchis sinensis]

CSR

*

TNF-α homology

IPS

40900

XP_002577301.1

Hypothetical protein [Schistosoma mansoni]

PDR (HT)/PSR

*

TGF-β stimulation

NCBI/GeneDB

42935/76935

GAA51525.1

CD2 antigen cytoplasmic tail-binding protein 2 [Clonorchis sinensis]

PDR (HT)/PDR (HT)

*

Proline binding

NCBI/NCBI

44058

XP_002578816.1

Bone morphogenetic protein antagonist noggin [Schistosoma mansoni]

CSR

*

TGF-β antagonist

IPS

44260

3Q5T_A

Chain A, V BetaV BETA HOMODIMERIZATION-Based Pre-Tcr Model Suggested By Tcr Beta Crystal Structures [Mus musculus]

PDR (HT)

 

T-cell receptor homology

NCBI

47252

XP_002575081.1

Suppressor of cytokine signaling [Schistosoma mansoni]

CSR

*

Suppressor of cytokine signalling

IPS

49819

GAA49058.1

Activin receptor type-1, partial [Clonorchis sinensis]

CSR

*

TGF-β receptor homology

IPS

53490/55117

XP_003946490.1

PREDICTED: h-2 class I histocompatibility antigen, D-D alpha chain-like isoform 7 [Mus musculus]

PDR (VT)/PDR (HT)

*

MHC class I homology

IPS/IPS

54791

AAA39576.1

MHC H2-K-d transplantation antigen H2-Kd, partial [Mus musculus]

PDR (VT)

*

MHC class I homology

NCBI

55207

XP_002570016.1

Protein kinase [Schistosoma mansoni]

CSR

*

TGF-β receptor homology

IPS

56418

XP_002570128.1

Bone morphogenetic protein antagonist noggin [Schistosoma mansoni]

CSR

*

TGF-β antagonist

IPS

56437

NP_001077023.1

Transforming growth factor-beta receptor-associated protein 1 homolog [Danio rerio]

CSR

 

TGF-β receptor homology

IPS

58384

1404428A

Cytotoxic T lymphocyte [Murid herpesvirus 1]

PDR (HT)

*

MHC class I homology

IPS

58628

GAA54758.1

TNF receptor-associated factor 4 [Clonorchis sinensis]

CSR

 

TNF receptor homology

IPS

58983

NM_001033288.3

Somatomedin B and thrombospondin, type 1 domain containing (Sbspon), mRNA [Mus musculus]

PDR (VT)

*

TGF-β stimulation

UniProt

59522

XP_003946048.1

PREDICTED: h-2 class I histocompatibility antigen, K-D alpha chain-like isoform 4 [Mus musculus]

PDR (VT)

*

MHC class I homology

IPS

59632

BAE26952.1

Unnamed protein product [Mus musculus]

CSR

*

CD48 homology

NCBI/IPS

59650

CAE82020.1

Unnamed protein product [Mus musculus]

PDR (VT)

*

MHC class I homology

NCBI

60918

GAA43145.2

Protein DVR-1 [Clonorchis sinensis]

CSR

*

TGF-β homology

IPS

61208

AAA39567.1

H-2D cell surface glycoprotein, partial [Mus musculus]

PDR (HT)

*

MHC class I homology

IPS

64619

BAE20821.1

Unnamed protein product [Mus musculus]

PDR (HT)

*

T-cell receptor homology

IPS

65009

1503111B

H2Dd gene [Mus musculus]

PDR (HT)

*

MHC class I homology

IPS

70639

CCD82741.1

T-cell immunomodulatory protein [Schistosoma mansoni]

PDR (HT)

*

Modulator of T-cell function

UniProt

72283

CAX74995.1

LIN1-like protein [Schistosoma japonicum]

PDR (HT)

*

Proline binding

NCBI

73151

CAA24128.1

H2-Ld [Mus musculus]

PDR (VT)

*

MHC class I homology

IPS

73578

EDL36365.1

mCG8696 [Mus musculus]

PDR (HT)

*

T-cell receptor homology

IPS

73673

EDL76957.1

Transforming growth factor, beta receptor II, isoform CRA_b [Rattus norvegicus]

CSR

*

TGF-β receptor homology

IPS

76453

BAE34022.1

Unnamed protein product [Mus musculus]

CSR

*

TGF-β receptor homology

IPS

77913

NP_034683.1

Interleukin-18 receptor accessory protein precursor [Mus musculus]

CSR

*

IL-18 receptor accessory protein homology

IPS

79120

Smp_060190.1

ctg4a [Schistosoma mansoni]

PDR (HT)

*

Toll like receptor 4 (TLR4) regulation

NCBI/GeneDB

  1. Virulence and immunomodulation-related transcripts of F. hepatica (VIRs) with accession and description of the corresponding sequences, identified by the transcript subgroups, are listed. The predicted immunomodulatory property function and the possibility for the host-parasite interaction (HPI) for VIRs are shown. Data resources for the categorisation and/or prediction of function are indicated. Most proteins inferred from VIRs (n = 63) were predicted to be possibly located in the extracellular space except a VIR protein which is possibly located at the cell plasma membrane. Accesion with description was obtained from the blast searches in the NCBI protein database or GeneDB (for only #79120). Asterisk (*) indicates potential association with extracellular localisation. Double asterisk (**) indicates potential association with plasma membrane location. No asterisk in the HPI column indicates the signs of cytoplasmic locations for the related transcripts except #3866, which showed the signs of being located in mitochondria and/or nucleus. IPS: InterProScan.
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BMC Genomics

ISSN: 1471-2164

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