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Table 1 Genotypes and phenotypes of in vitro mutants and clinical isolates with fabI promoter mutations

From: Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression

Strain

Background

sa-fabI promoter**

sa - fabI

sh - fabI

MIC*

MBC*

Comment

RN4220

-

wt

wt

-

1

2

 

MW2

-

wt

wt

-

0.12

0.12

 

ATCC6538

-

wt

wt

-

0.12

0.25

 

MO036

RN4220

A7G

mutated

-

4

8

 

MO035

RN4220

C34T

mutated

-

8

8

 

MO047

RN4220

C34T

mutated

-

4

8

 

MO049

RN4220

C34T

mutated

-

4

8

 

MO076

MW2

C34T

mutated

-

4

8

 

CR002

ATCC6538

C34T

mutated

-

4

8

 

MO034

RN4220

A72G

mutated

-

8

8

 

MO077

MW2

A101-

mutated

-

4

32

1 bp deletion

d7

ATCC6538

A101-

mutated

-

2

8

1 bp deletion

MO051

ATCC6538

T109G

mutated

-

4

8

 

MO052

ATCC6538

T109G

mutated

-

8

16

 

MO053

ATCC6538

T109G

mutated

-

4

8

 

MO055

ATCC6538

T109G

mutated

-

4

8

 

QBR-102278-1097

-

C34T

mutated

-

0.25

32

 

QBR-102278-1889

-

C34T

wt

-

0.5

16

 

QBR-102278-1969

-

C34T

wt

-

0.25

32

 

QBR-102278-2095

-

C34T

wt

-

0.25

32

 

QBR-102278-2546

-

C34T

mutated

+

1

64

 

QBR-102278-2363

-

A101C

wt

+

16

32

 

QBR-102278-1052

-

T109G

wt

+

0.5

64

IS256 insertion

  1. *MIC and MBC to triclosan are expressed as mg/L. **Polymorphic sites are indicated counting backwards from the sa-fabI start site of S. aureus Mu50 (GenBank ID: BA000017; position 1060308). Strains analysed by microarray are indicated in bold. With the exception of strain QBR-102278-2095, these data have been previously reported [22].