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Table 1 Genotypes and phenotypes of in vitro mutants and clinical isolates with fabI promoter mutations

From: Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression

Strain Background sa-fabI promoter** sa - fabI sh - fabI MIC* MBC* Comment
RN4220 - wt wt - 1 2  
MW2 - wt wt - 0.12 0.12  
ATCC6538 - wt wt - 0.12 0.25  
MO036 RN4220 A7G mutated - 4 8  
MO035 RN4220 C34T mutated - 8 8  
MO047 RN4220 C34T mutated - 4 8  
MO049 RN4220 C34T mutated - 4 8  
MO076 MW2 C34T mutated - 4 8  
CR002 ATCC6538 C34T mutated - 4 8  
MO034 RN4220 A72G mutated - 8 8  
MO077 MW2 A101- mutated - 4 32 1 bp deletion
d7 ATCC6538 A101- mutated - 2 8 1 bp deletion
MO051 ATCC6538 T109G mutated - 4 8  
MO052 ATCC6538 T109G mutated - 8 16  
MO053 ATCC6538 T109G mutated - 4 8  
MO055 ATCC6538 T109G mutated - 4 8  
QBR-102278-1097 - C34T mutated - 0.25 32  
QBR-102278-1889 - C34T wt - 0.5 16  
QBR-102278-1969 - C34T wt - 0.25 32  
QBR-102278-2095 - C34T wt - 0.25 32  
QBR-102278-2546 - C34T mutated + 1 64  
QBR-102278-2363 - A101C wt + 16 32  
QBR-102278-1052 - T109G wt + 0.5 64 IS256 insertion
  1. *MIC and MBC to triclosan are expressed as mg/L. **Polymorphic sites are indicated counting backwards from the sa-fabI start site of S. aureus Mu50 (GenBank ID: BA000017; position 1060308). Strains analysed by microarray are indicated in bold. With the exception of strain QBR-102278-2095, these data have been previously reported [22].