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Table 4 fabI / gyrA ratio of laboratory and clinical strains

From: Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression

Strains Log 2 fabI/gyrA ratio* t test vs
parental strain 		t test vs ATCC 6538 t test vs ATCC25923
Laboratory strains     
RN4220 (n = 6) 1.69    
MO034 (n = 5) 2.49 0.04   
MO035 (n = 5) 3.37 0.0002   
MO036 (n = 3) 1.41 ns   
MU50 (n = 5) −0.28    
ATCC6538 (n = 4) 0.14    
MO052 (n = 4) 2.14 0.0002   
ATCC25923 (n = 4) −0.51    
Clinical strains     
QBR-102278-1052 (n = 4) 4.22   <0.0001 <0.0001
QBR-102278-1889 (n = 4) 1.25   0.0026 0.0137
QBR-102278-1969 (n = 4) 1.56   0.0002 0.0059
QBR-102278-2363 (n = 4) 1.16   0.004 0.016
QBR-102278-1016 (n = 3) 0.23   ns ns
QBR-102278-1027 (n = 4) 0.13   ns ns
QBR-102278-2628 (n = 5) 0.03   ns ns
  1. *Log2 ratio was independently determined for each chip using the data before stage-wise quantile normalization, by subtracting the Log2 mean gyrA values obtained from the eight probes for gyrA printed on the chip from the Log2 mean fabI values from the two probes. Ratio was then further averaged for the number of chips used by strains (n). Student’s unpaired t-test was performed by comparing the mutants to their parental strains in the case of laboratory strains, or to two reference strains in the case of clinical isolates. ns = not significant.
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BMC Genomics

ISSN: 1471-2164

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