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Table 1 Selected variant positions

From: Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over

Line code and phenotype class Expected mode of inheritance Selected genotype in vcf file Number of animals sequenced Private variant positions Variant positions in exons Variant positions in exons (one per gene) Variants in linkage region Variant positions with ENU- type base changes Variant positions in concordance with phenotype
Line 1 body weight Recessive 1/1 4 3 1 1 No region available 1 No position confirmed
Line 2 body size Dominant 0/1 4 9 3 3 No region available 2 1 (confirmed by Sanger)
Line 3 hormone level Dominant 0/1 4 9 3 3 No region available 2 1 position in line for validation
Line 4 enzymatic level Recessive 1/1 4 1 1 1 1 0 1 position related to the phenotype
Line 5 hormone level Dominant 0/1 2 136 10 10 No region available 6 4 positions related to the phenotype
Line 6 dental phenotype Dominant 0/1 2 176 12 10 No region available 4 1 (confirmed by Sanger, manuscript under review)
Line 7 body weight Dominant 0/1 2 64 14 12 1 5 1 (confirmed by Sanger)
Line 8 body size Dominant 0/1 2 100 23 23 1 16 No position confirmed
  1. The table summarizes mutant line information, genotypes of interest, numbers of variants at several stages of filtering, numbers of variants with one of the predominant ENU-induced base changes, and numbers of variant positions inside genes relating to the phenotype of each line.