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Table 1 Selected variant positions

From: Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over

Line code and phenotype class

Expected mode of inheritance

Selected genotype in vcf file

Number of animals sequenced

Private variant positions

Variant positions in exons

Variant positions in exons (one per gene)

Variants in linkage region

Variant positions with ENU- type base changes

Variant positions in concordance with phenotype

Line 1 body weight

Recessive

1/1

4

3

1

1

No region available

1

No position confirmed

Line 2 body size

Dominant

0/1

4

9

3

3

No region available

2

1 (confirmed by Sanger)

Line 3 hormone level

Dominant

0/1

4

9

3

3

No region available

2

1 position in line for validation

Line 4 enzymatic level

Recessive

1/1

4

1

1

1

1

0

1 position related to the phenotype

Line 5 hormone level

Dominant

0/1

2

136

10

10

No region available

6

4 positions related to the phenotype

Line 6 dental phenotype

Dominant

0/1

2

176

12

10

No region available

4

1 (confirmed by Sanger, manuscript under review)

Line 7 body weight

Dominant

0/1

2

64

14

12

1

5

1 (confirmed by Sanger)

Line 8 body size

Dominant

0/1

2

100

23

23

1

16

No position confirmed

  1. The table summarizes mutant line information, genotypes of interest, numbers of variants at several stages of filtering, numbers of variants with one of the predominant ENU-induced base changes, and numbers of variant positions inside genes relating to the phenotype of each line.