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Table 3 Differential allelic ratio groups between local recurrence and control

From: Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

A)

Local recurrence group

Control group

Chr.

p-value

BH

Retention

Imbalance

LOH

Retention

Imbalance

LOH

1q

0.05

0.17

89%

11%

0%

45%

53%

2%

4q

0.05

0.17

78%

22%

0%

47%

22%

31%

7p

0.0005

0.015

100%

0%

0%

36%

62%

2%

7q

0.0007

0.015

100%

0%

0%

9%

13%

78%

10p

0.04

0.17

89%

11%

0%

53%

45%

2%

11p

0.04

0.17

89%

11%

0%

49%

42%

9%

13q

0.04

0.17

78%

11%

11%

27%

60%

13%

14q

0.017

0.17

78%

22%

0%

40%

22%

38%

15q

0.03

0.17

78%

22%

0%

29%

29%

42%

16q

0.06

0.18

89%

11%

0%

53%

36%

11%

17p

0.03

0.17

22%

33%

44%

9%

13%

78%

18q

0.05

0.17

11%

22%

67%

9%

13%

78%

22q

0.04

0.17

78%

11%

11%

33%

31%

36%

B)

Local recurrence group

Control group

Chr.

p-value

 

Retention

Imbalance

LOH

Retention

Imbalance

LOH

7

0.0025

 

9

0

0

19

25

1

13

0.0062

 

7

1

1

12

27

6

7 + 13

<0.0002

 

7

1

1

5

33

7

  1. A) For comparison of the local recurrence group and control group, chromosome arms are listed that showed significant allelic ratio groups with p-values <0.05 and adjusted p-values <0.2.
  2. Abbreviations: Chr, chromosome; B, p-value after using the Benjamin-Hochberg method for multiple testing correction.
  3. B) For chromosome 7, chromosome 13 and in combination, the numbers of patients within each ‘overall chromosome status’ group - defined as the most abundant allelic ratio group on the chromosome - are shown for both the local recurrence group (L) and the control group (C). Fisher’s exact test for count data was used to determine the statistical differences between analysis groups L and C.
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BMC Genomics

ISSN: 1471-2164

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