Human NRSEs are associated with lncRNAs genome-wide but not in gene-distant regions. A. 17-24% of NRSE motifs in the human, mouse and frog genomes are located in gene-distant regions (GD). B. In the human genome, NRSEs within 100 kb of ncRNAs are associated with lncRNAs (chi-square, p = 0.00102547). In the figure, <100 kb denotes the NRSEs that are within 100 kb of a protein-coding gene and >100 kb is for NRSEs that are located in GD.