Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Table 2 Selected phenotypic and genomic antibiotic resistance profiles in strains of ST772-MRSA-V

Antibiotic	Phenotype (MIC μg/L)		Resistance Genes and Mutations in ST772-MRSA-V
	DAR4145		DAR4145	07-17048	KT/Y21	118	120	333	3957	3989	LVP2	VH60
Oxacillin	R (≥4)	mecA (M)	+	+	+	+	+	+	+	+	+	+
		blaZ *(M)*	+	+	+	+	+	+	+	+	+	+
		blaZ *(P)*	+	-	+	+	+/−	-	-	+	+	+
Gentamicin	R (≥16)	aacA-aphD (M)	+	+	+	-	+	+	+	+	+	+
Gentamicin	R (≥16)	aphA-III, sat4, aadE(p) (P)	+	+	+	+/−	+	-	-	+	+	+
Trimethoprim/Sulfamethoxazole	R (≥320)	dfrA (C)	+	+	+	+	+	+	+	+	+	+
		dfrG (C)	+	-	-	-	+	+	-	+	+	+
		dfrG (M)	+	+	+	+	-	-	+	-	-	-
Ciprofloxacin Levofloxacin Moxifloxacin	R (4) R (4) I (1)	norA/norB (C)	+	+	+	+	+	+	+	+	+	+
		grlA (S80T/F)	+	+	+	+	+	+	+	+	+	+
		gyrA (S84L)	+	+	+	+	+	+	+	+	+	+
Tetracyline	S (≤1)	tet(38) (C)	+	+	+	+	+	+	+	+	+	+
Erythromicin Clindamycin	I (1) S ( ≤0.25)	msrA-mphC (P)	+	+	+	+	+	-	-	+	+	+

(R = Resistant, I = Intermediate, S = Susceptible,C = Chromosomal, M = Mobile Genetic Element, P = Integrated Resistance Plasmid, + = present, − = absent, p = partial, +/− = partial or truncated).

ISSN: 1471-2164