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Fig. 5 | BMC Genomics

Fig. 5

From: Controlling for conservation in genome-wide DNA methylation studies

Fig. 5

The YS effect can bias comparative studies of DNA methylation across different conditions and cell types. The matrices above represent a hypothetical setting of a functional boundary and the methylation rates measured at the different genomic locations, as specified in Fig. 1 (each row corresponds to a hypothetical instance, e.g. a specific intron-exon junction, and each column to a relative location in relation to the boundary analyzed, e.g. +1 from the intron-exon boundary). This example shows that, due to the YS effect, regional changes in DNA methylation intensity that are not associated with a functional boundary can be misleading when analyzed with the %mCG statistic

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