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Table 1 List of top 140 SNPs (p <0.00001) from GWAS analysis that were predictive of triptolide cytotoxicity in HapMap LCLs

From: Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

SNP Position Minor Allele MAF r.ic50 p value Chr Gene_function_list
rs6759004 202004676 C 0.15 −0.63 2.51E-07 2 CFLAR/intron
rs10931931 201994540 C 0.15 −0.62 3.66E-07 2 CFLAR/UTR-5
rs13413479 202012578 G 0.15 −0.62 3.66E-07 2 CFLAR/intron
rs73045343 202017408 G 0.15 −0.62 3.66E-07 2 CFLAR/intron
rs6712963 201982693 G 0.15 −0.62 3.78E-07 2 CFLAR/intron
rs10469755 201917938 T 0.17 −0.62 4.43E-07 2 FAM126B/intron
rs13059218 26910495 A 0.24 0.62 5.11E-07 3  
rs73045306 202000395 C 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs6759216 202004710 G 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs10203550 202009586 G 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs13426823 202015677 G 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs12105811 202016245 A 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs73045341 202016550 G 0.17 −0.61 6.01E-07 2 CFLAR/intron
rs111315781 201738724 T 0.14 −0.61 6.27E-07 2 PPIL3/intron
rs73439953 56602702 T 0.33 −0.61 7.51E-07 18 ZNF532/intron
c2.201734921.b37p0 201734921 G 0.14 −0.61 9.19E-07 2  
rs55953858 201997292 G 0.21 −0.60 1.66E-06 2 CFLAR/intron
rs4035022 201744352 A 0.15 −0.59 1.76E-06 2 PPIL3/intron
rs3851973 201732878 G 0.14 −0.59 1.79E-06 2 PPIL3/UTR-5 and CLK1/UTR-3
rs111976464 201735042 C 0.14 −0.59 1.79E-06 2 PPIL3/UTR-5 and CLK1/UTR-3
rs11892119 201736112 C 0.14 −0.59 1.79E-06 2 PPIL3/UTR-3
rs7562391 201736166 C 0.14 −0.59 1.79E-06 2 PPIL3/missense
rs7560613 202003010 C 0.21 −0.60 1.83E-06 2 CFLAR/intron
rs6747253 201748415 A 0.15 −0.59 2.17E-06 2 PPIL3/intron
rs73043383 201968246 C 0.17 −0.59 2.19E-06 2 CFLAR/UTR-5
rs7591472 201889751 C 0.17 −0.59 2.20E-06 2 FAM126B/intron
rs10194347 201942480 A 0.17 −0.59 2.42E-06 2 NDUFB3/intron
rs28405687 201906661 T 0.23 −0.59 2.52E-06 2 FAM126B/intron
rs915650 37657526 A 0.38 −0.59 2.54E-06 8  
rs7583529 201988238 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs6728771 201992407 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs6706980 201993688 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs58886660 201999283 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs28636431 201999550 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs7573256 202003170 G 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs113350756 202003767 G 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs10190751 202006096 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs56160734 202006860 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs4487072 202008298 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs1981726 202008700 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs7573529 202010626 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs13387186 202012068 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs13413075 202012363 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs12104442 202013956 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs12721505 202014238 G 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs7571899 202015028 G 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs7585993 202015114 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs61289882 202015250 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs68044560 202017080 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs56863085 202017647 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs719125 202017860 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs56009967 202019094 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs56161269 202019210 A 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs2041766 202021495 T 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs4482462 202021747 C 0.21 −0.59 2.57E-06 2 CFLAR/intron
rs75518195 65067404 G 0.36 0.58 2.80E-06 4 nearest gene (~150 kb down TECRL)
rs13384245 201760937 G 0.17 −0.58 2.89E-06 2 NIF3L1/intron
rs10204787 201762147 A 0.17 −0.58 2.89E-06 2 NIF3L1/intron
rs113388793 201771341 G 0.17 −0.58 2.89E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs2307358 201785657 T 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs2307362 201785837 A 0.17 −0.58 2.89E-06 2 ORC2/cds-synon
rs4622700 201793113 T 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs9288314 201794173 T 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs10185727 201803711 G 0.17 −0.58 2.89E-06 2 ORC2/intron
rs13408964 201804972 T 0.17 −0.58 2.89E-06 2 ORC2/intron
rs16836160 201813830 G 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs13429609 201816257 T 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs13392371 201816421 A 0.17 −0.58 2.89E-06 2 ORC2/Intron
rs16836477 201853457 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs6719992 201871978 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs13405753 201881677 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs10197103 201885293 T 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs13384791 201911164 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs13417843 201913429 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs10207746 201916418 C 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs73043345 201920060 G 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs13389349 201920618 C 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs6737556 201924078 T 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs7590522 201924788 T 0.17 −0.58 2.89E-06 2 FAM126B/intron
rs10194168 201942437 T 0.17 −0.58 2.89E-06 2 NDUFB3/intron
rs10205971 201958201 G 0.17 −0.58 2.89E-06 2 NDUFB3/UTR-5 and CFLAR/UTR-5
rs2110728 201965678 A 0.17 −0.58 2.89E-06 2 CFLAR/UTR-5
rs13421776 201760902 G 0.19 −0.58 3.33E-06 2 NIF3L1/intron
rs4381763 201776988 G 0.19 −0.58 3.33E-06 2 ORC2/intron
rs10183261 201797676 A 0.19 −0.58 3.33E-06 2 ORC2/intron
rs10205561 201809704 T 0.19 −0.58 3.33E-06 2 ORC2/Intron
rs2307357 201824092 A 0.19 −0.58 3.33E-06 2 ORC2/Intron
rs3087357 201828365 G 0.19 −0.58 3.33E-06 2 ORC2/UTR-5
rs874358 201829602 G 0.19 −0.58 3.33E-06 2 ORC2/UTR-5
rs3900738 201863803 A 0.19 −0.58 3.33E-06 2 FAM126B/intron
rs16836568 201879948 G 0.19 −0.58 3.33E-06 2 FAM126B/intron
rs13416500 201771798 A 0.18 −0.58 3.63E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs13404596 201771801 T 0.19 −0.58 3.63E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs6757272 201728141 A 0.35 −0.58 4.14E-06 2 CLK1/intron
rs10184098 202004190 G 0.21 −0.57 4.45E-06 2 CFLAR/intron
rs28447044 64903606 T 0.46 0.57 4.69E-06 4 nearest gene (250 kb down TECRL)
rs11660954 56603803 G 0.26 −0.57 5.27E-06 18 ZNF532/intron
rs34044649 155655693 T 0.42 −0.57 5.59E-06 7  
c14.20107162.b37p0 20107162 C 0.24 0.73 5.84E-06 14  
rs2950160 4420188 G 0.31 −0.57 5.96E-06 8 CSMD1/intron
c18.56609415.b37p0 56609415 T 0.24 −0.57 6.60E-06 18  
rs9854411 171921569 C 0.16 −0.57 6.70E-06 3 FNDC3B/intron
rs13412214 201774182 T 0.23 −0.56 7.21E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs13412430 201774355 T 0.23 −0.56 7.21E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs10172647 201778950 A 0.23 −0.56 7.29E-06 2 ORC2/intron
rs3125719 29990966 T 0.18 −0.56 7.30E-06 13 MTUS2/intron
c2.201899549.b37p0 201899549 C 0.17 −0.56 7.35E-06 2  
rs6445044 171920569 G 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6414541 171920637 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs3923825 171922127 T 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs3924140 171926314 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs4610256 171928021 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6445045 171928400 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs9867872 171928985 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs9868872 171929530 G 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs4380442 171930381 A 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6763764 171931389 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6803181 171932256 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6780871 171932606 G 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs6806070 171932935 C 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs7619745 171933571 A 0.16 −0.56 7.48E-06 3 FNDC3B/intron
rs2016325 66323500 T 0.35 0.56 7.68E-06 7  
rs6435066 201766023 G 0.23 −0.56 8.00E-06 2 NIF3L1/intron
rs7917 201768238 T 0.23 −0.56 8.00E-06 2 NIF3L1/missense
rs11894842 201773545 C 0.23 −0.56 8.00E-06 2 NIF3L1/UTR-3 and ORC2/UTR-3
rs10167387 201808618 C 0.23 −0.56 8.00E-06 2 ORC2/Intron
rs68133847 201812251 G 0.23 −0.56 8.00E-06 2 ORC2/Intron
rs11892372 201819483 A 0.23 −0.56 8.00E-06 2 ORC2/Intron
rs3901120 201863530 C 0.23 −0.56 8.00E-06 2 FAM126B/intron
rs16836591 201894943 T 0.23 −0.56 8.00E-06 2 FAM126B/intron
rs10185136 201904301 T 0.23 −0.56 8.00E-06 2 FAM126B/intron
rs10197833 201904466 C 0.23 −0.56 8.00E-06 2 FAM126B/intron
rs16842071 201931730 C 0.23 −0.56 8.00E-06 2 FAM126B/intron
rs13410282 201971024 A 0.23 −0.56 8.00E-06 2 CFLAR/UTR-5
rs16836710 201999845 T 0.19 −0.57 8.39E-06 2 CFLAR/intron
rs61457372 70359774 C 0.35 0.56 8.73E-06 17  
rs6841405 65067406 G 0.4 0.56 8.86E-06 4 nearest gene (~150 kb down TECRL)
rs7597409 201893188 T 0.23 −0.56 8.97E-06 2 FAM126B/intron
rs12723025 223977519 T 0.073 0.56 9.06E-06 1 TP53BP2/intron
rs6754564 201779932 C 0.16 −0.56 9.69E-06 2 ORC2/Intron