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Table 1 List of top 140 SNPs (p <0.00001) from GWAS analysis that were predictive of triptolide cytotoxicity in HapMap LCLs

From: Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

SNP

Position

Minor Allele

MAF

r.ic50

p value

Chr

Gene_function_list

rs6759004

202004676

C

0.15

−0.63

2.51E-07

2

CFLAR/intron

rs10931931

201994540

C

0.15

−0.62

3.66E-07

2

CFLAR/UTR-5

rs13413479

202012578

G

0.15

−0.62

3.66E-07

2

CFLAR/intron

rs73045343

202017408

G

0.15

−0.62

3.66E-07

2

CFLAR/intron

rs6712963

201982693

G

0.15

−0.62

3.78E-07

2

CFLAR/intron

rs10469755

201917938

T

0.17

−0.62

4.43E-07

2

FAM126B/intron

rs13059218

26910495

A

0.24

0.62

5.11E-07

3

 

rs73045306

202000395

C

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs6759216

202004710

G

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs10203550

202009586

G

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs13426823

202015677

G

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs12105811

202016245

A

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs73045341

202016550

G

0.17

−0.61

6.01E-07

2

CFLAR/intron

rs111315781

201738724

T

0.14

−0.61

6.27E-07

2

PPIL3/intron

rs73439953

56602702

T

0.33

−0.61

7.51E-07

18

ZNF532/intron

c2.201734921.b37p0

201734921

G

0.14

−0.61

9.19E-07

2

 

rs55953858

201997292

G

0.21

−0.60

1.66E-06

2

CFLAR/intron

rs4035022

201744352

A

0.15

−0.59

1.76E-06

2

PPIL3/intron

rs3851973

201732878

G

0.14

−0.59

1.79E-06

2

PPIL3/UTR-5 and CLK1/UTR-3

rs111976464

201735042

C

0.14

−0.59

1.79E-06

2

PPIL3/UTR-5 and CLK1/UTR-3

rs11892119

201736112

C

0.14

−0.59

1.79E-06

2

PPIL3/UTR-3

rs7562391

201736166

C

0.14

−0.59

1.79E-06

2

PPIL3/missense

rs7560613

202003010

C

0.21

−0.60

1.83E-06

2

CFLAR/intron

rs6747253

201748415

A

0.15

−0.59

2.17E-06

2

PPIL3/intron

rs73043383

201968246

C

0.17

−0.59

2.19E-06

2

CFLAR/UTR-5

rs7591472

201889751

C

0.17

−0.59

2.20E-06

2

FAM126B/intron

rs10194347

201942480

A

0.17

−0.59

2.42E-06

2

NDUFB3/intron

rs28405687

201906661

T

0.23

−0.59

2.52E-06

2

FAM126B/intron

rs915650

37657526

A

0.38

−0.59

2.54E-06

8

 

rs7583529

201988238

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs6728771

201992407

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs6706980

201993688

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs58886660

201999283

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs28636431

201999550

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs7573256

202003170

G

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs113350756

202003767

G

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs10190751

202006096

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs56160734

202006860

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs4487072

202008298

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs1981726

202008700

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs7573529

202010626

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs13387186

202012068

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs13413075

202012363

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs12104442

202013956

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs12721505

202014238

G

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs7571899

202015028

G

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs7585993

202015114

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs61289882

202015250

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs68044560

202017080

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs56863085

202017647

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs719125

202017860

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs56009967

202019094

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs56161269

202019210

A

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs2041766

202021495

T

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs4482462

202021747

C

0.21

−0.59

2.57E-06

2

CFLAR/intron

rs75518195

65067404

G

0.36

0.58

2.80E-06

4

nearest gene (~150 kb down TECRL)

rs13384245

201760937

G

0.17

−0.58

2.89E-06

2

NIF3L1/intron

rs10204787

201762147

A

0.17

−0.58

2.89E-06

2

NIF3L1/intron

rs113388793

201771341

G

0.17

−0.58

2.89E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs2307358

201785657

T

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs2307362

201785837

A

0.17

−0.58

2.89E-06

2

ORC2/cds-synon

rs4622700

201793113

T

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs9288314

201794173

T

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs10185727

201803711

G

0.17

−0.58

2.89E-06

2

ORC2/intron

rs13408964

201804972

T

0.17

−0.58

2.89E-06

2

ORC2/intron

rs16836160

201813830

G

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs13429609

201816257

T

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs13392371

201816421

A

0.17

−0.58

2.89E-06

2

ORC2/Intron

rs16836477

201853457

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs6719992

201871978

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs13405753

201881677

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs10197103

201885293

T

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs13384791

201911164

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs13417843

201913429

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs10207746

201916418

C

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs73043345

201920060

G

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs13389349

201920618

C

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs6737556

201924078

T

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs7590522

201924788

T

0.17

−0.58

2.89E-06

2

FAM126B/intron

rs10194168

201942437

T

0.17

−0.58

2.89E-06

2

NDUFB3/intron

rs10205971

201958201

G

0.17

−0.58

2.89E-06

2

NDUFB3/UTR-5 and CFLAR/UTR-5

rs2110728

201965678

A

0.17

−0.58

2.89E-06

2

CFLAR/UTR-5

rs13421776

201760902

G

0.19

−0.58

3.33E-06

2

NIF3L1/intron

rs4381763

201776988

G

0.19

−0.58

3.33E-06

2

ORC2/intron

rs10183261

201797676

A

0.19

−0.58

3.33E-06

2

ORC2/intron

rs10205561

201809704

T

0.19

−0.58

3.33E-06

2

ORC2/Intron

rs2307357

201824092

A

0.19

−0.58

3.33E-06

2

ORC2/Intron

rs3087357

201828365

G

0.19

−0.58

3.33E-06

2

ORC2/UTR-5

rs874358

201829602

G

0.19

−0.58

3.33E-06

2

ORC2/UTR-5

rs3900738

201863803

A

0.19

−0.58

3.33E-06

2

FAM126B/intron

rs16836568

201879948

G

0.19

−0.58

3.33E-06

2

FAM126B/intron

rs13416500

201771798

A

0.18

−0.58

3.63E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs13404596

201771801

T

0.19

−0.58

3.63E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs6757272

201728141

A

0.35

−0.58

4.14E-06

2

CLK1/intron

rs10184098

202004190

G

0.21

−0.57

4.45E-06

2

CFLAR/intron

rs28447044

64903606

T

0.46

0.57

4.69E-06

4

nearest gene (250 kb down TECRL)

rs11660954

56603803

G

0.26

−0.57

5.27E-06

18

ZNF532/intron

rs34044649

155655693

T

0.42

−0.57

5.59E-06

7

 

c14.20107162.b37p0

20107162

C

0.24

0.73

5.84E-06

14

 

rs2950160

4420188

G

0.31

−0.57

5.96E-06

8

CSMD1/intron

c18.56609415.b37p0

56609415

T

0.24

−0.57

6.60E-06

18

 

rs9854411

171921569

C

0.16

−0.57

6.70E-06

3

FNDC3B/intron

rs13412214

201774182

T

0.23

−0.56

7.21E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs13412430

201774355

T

0.23

−0.56

7.21E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs10172647

201778950

A

0.23

−0.56

7.29E-06

2

ORC2/intron

rs3125719

29990966

T

0.18

−0.56

7.30E-06

13

MTUS2/intron

c2.201899549.b37p0

201899549

C

0.17

−0.56

7.35E-06

2

 

rs6445044

171920569

G

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6414541

171920637

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs3923825

171922127

T

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs3924140

171926314

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs4610256

171928021

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6445045

171928400

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs9867872

171928985

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs9868872

171929530

G

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs4380442

171930381

A

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6763764

171931389

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6803181

171932256

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6780871

171932606

G

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs6806070

171932935

C

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs7619745

171933571

A

0.16

−0.56

7.48E-06

3

FNDC3B/intron

rs2016325

66323500

T

0.35

0.56

7.68E-06

7

 

rs6435066

201766023

G

0.23

−0.56

8.00E-06

2

NIF3L1/intron

rs7917

201768238

T

0.23

−0.56

8.00E-06

2

NIF3L1/missense

rs11894842

201773545

C

0.23

−0.56

8.00E-06

2

NIF3L1/UTR-3 and ORC2/UTR-3

rs10167387

201808618

C

0.23

−0.56

8.00E-06

2

ORC2/Intron

rs68133847

201812251

G

0.23

−0.56

8.00E-06

2

ORC2/Intron

rs11892372

201819483

A

0.23

−0.56

8.00E-06

2

ORC2/Intron

rs3901120

201863530

C

0.23

−0.56

8.00E-06

2

FAM126B/intron

rs16836591

201894943

T

0.23

−0.56

8.00E-06

2

FAM126B/intron

rs10185136

201904301

T

0.23

−0.56

8.00E-06

2

FAM126B/intron

rs10197833

201904466

C

0.23

−0.56

8.00E-06

2

FAM126B/intron

rs16842071

201931730

C

0.23

−0.56

8.00E-06

2

FAM126B/intron

rs13410282

201971024

A

0.23

−0.56

8.00E-06

2

CFLAR/UTR-5

rs16836710

201999845

T

0.19

−0.57

8.39E-06

2

CFLAR/intron

rs61457372

70359774

C

0.35

0.56

8.73E-06

17

 

rs6841405

65067406

G

0.4

0.56

8.86E-06

4

nearest gene (~150 kb down TECRL)

rs7597409

201893188

T

0.23

−0.56

8.97E-06

2

FAM126B/intron

rs12723025

223977519

T

0.073

0.56

9.06E-06

1

TP53BP2/intron

rs6754564

201779932

C

0.16

−0.56

9.69E-06

2

ORC2/Intron

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