Table 2 Top biological functions of genes differentially expressed between Wooden Breast myopathy-affected and unaffected birds as presented by Ingenuity Pathway Analysis (IPA®)
Biological Functions | P-value | # Molecules | |
|---|---|---|---|
Diseases and disorders: | |||
Cancer | 3.18E-31 – 4.08E-05 | 1208 | |
Gastrointestinal Disease | 9.84E-26 – 3.06E-05 | 890 | |
Cardiovascular Disease | 7.45E-21 – 4.06E-05 | 293 | |
Hepatic System Disease | 1.86E-20 – 3.06E-05 | 593 | |
Neurological Disease | 1.95E-17 – 3.92E-05 | 407 | |
Molecular and Cellular Functions: | |||
Cellular Assembly and Organization | 7.25E-19 – 1.14E-05 | 321 | |
Cellular Function and Maintenance | 7.25E-19 – 2.06E-05 | 402 | |
Cellular Movement | 1.80E-17 – 3.43E-05 | 322 | |
Cell Morphology | 1.51E-16 – 2.53E-05 | 387 | |
Cellular Growth and Proliferation | 2.81E-16 – 3.82E-05 | 476 | |
Physiological System Development and Function: | |||
Nervous System Development/Function | 9.74E-14 – 3.90E-05 | 195 | |
Tissue Development | 9.74E-14 – 3.82E-05 | 501 | |
Cardiovascular System Dev./Function | 2.75E-13 – 3.70E-05 | 237 | |
Organismal Development | 5.44E-13 – 3.63E-05 | 432 | |
Embryonic Development | 9.51E-13 – 3.10E-05 | 306 | |
Top Canonical Pathways: | P-Value | Genes | Ratio |
Hepatic Fibrosis/Stellate Cell Activation | 2.83E-12 | 43/197 | 0.218 |
Epithelial Adherens Junction Signaling | 2.39E-08 | 30/146 | 0.205 |
Actin Cytoskeleton Signaling | 3.18E-07 | 36/217 | 0.166 |
Axonal Guidance Signaling | 1.27E-06 | 56/433 | 0.129 |
Coagulation System | 1.39E-06 | 12/35 | 0.343 |