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Table 3 Summary of main categories of genes involved in Wooden Breast myopathy separated by category

From: Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNA-sequencing

Gene category

Gene name

Symbol

RNA-seq fold change

Nanostring fold change

Fiber-Type Switching:

 

Myoglobin

MB

14.3

12.4

 

Myosin Binding Protein C, slow type

MYBPC1

9.1

16.2

 

Myozenin 2

MYOZ2

7.8

7.7

 

Troponin I type I, skeletal slow

TNNI1

4.0

N/A

Intracellular Calcium:

 

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

ATP2A2

2.1

N/A

 

Cytosolic phospholipase A2

PLA2G4A

2.3

N/A

 

Parvalbumin

PVALB

8.1

7.2

 

Phospholipase B1

PLB1

3.4

N/A

Hypoxia:

 

6-phophofructo-2-kinase

PFKFB3

−4.1

N/A

 

Arylhydrocarbon Receptor Nuclear Translocator 2

ARNT2

2.2

1.7

 

Asparagine synthetase

ASNS

4.4

N/A

 

Matrix metallopeptidase 2

MMP2

2.2

N/A

 

Muscle-specific carbonic anhydrase III

CA3

28.5

25.5

 

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

PLOD2

2.5

N/A

 

Transforming growth factor beta 3

TGFB3

3.9

3.7

 

Transient receptor potential cation channel, subfamily A

TRPA1

6.7

N/A

Oxidative Stress:

 

Corticotrophin-releasing hormone

CRH

14.3

13.3

 

FK506 binding protein

FKBP51

−1.9

N/A

 

Glutathione peroxidase 7

GPX7

2.3

N/A

 

Glutathione peroxidase 8

GPX8

2.1

N/A

 

Heat shock 27 kDa protein family, member 7

HSPB7

3.2

4.3

 

Heat shock 70 kDa protein 4-like protein

HSPA4L

1.5

N/A

 

Heat shock 105 kDa/110 kDa protein 1

HSPH1

2.2

N/A

 

Heat shock transcription factor 2

HSF2

2.9

N/A

 

Muscle-specific carbonic anhydrase III

CA3

28.5

25.5

 

Selenoprotein O

SELO

−2.1

N/A

Cellular Repair:

 

ADAM metallopeptidase domain 12

ADAM12

2.2

N/A

 

Cysteine and glycine-rich protein 3

CSRP3

23.2

27.3

 

Epidermal growth factor

EGF

1.6

N/A

 

Fibroblast growth factor 1

FGF1

−2.1

−1.9

 

Fibroblast growth factor10

FGF10

2.4

1.3

 

Musculoskeletal embryonic nuclear protein 1

MUSTN1

4.9

6.0

 

Myosin, heavy chain 13, skeletal muscle

MYH13

−4.7

1.0

 

Myosin, light chain 2, skeletal slow

MYL3

5.4

1.5

 

Myosin, light chain 12A regulatory

MYL12A

1.9

N/A

 

Myosin light chain kinase 2

MYLK2

−2.6

N/A

 

Nephroblastoma Overexpressed

NOV

7.3

3.0

 

Rho GTPase activating protein 10

ARHGAP10

2.2

N/A

 

Rho GTPase activating protein 20

ARHGAP20

2.4

N/A

 

Rho GTPase activating protein 40

ARHGAP40

3.0

2.8

 

Rho-related BTB domain containing 3

RHOBTB3

−11.9

−5.1

 

Sema domain, Ig, short basic domain, secreted, 3A

SEMA3A

1.6

N/A

  1. For each gene category, the complete gene name, symbol, fold change from RNA-seq data, and fold change from Nanostring® data are provided. Positive and negative fold change values support respectively upregulation and downregulation of gene expression in birds affected by Wooden Breast myopathy relative to the gene expression in unaffected birds
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BMC Genomics

ISSN: 1471-2164

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